Atherosclerotic Risk Factors and Premature Atherosclerosis in Acromegaly Before and After 48 Months of Octreotide-LAR Treatment

We studied premature atherosclerosis with carotid Doppler ultrasonography in active acromegaly before and after treatment. Patients (n = 27) with active acromegaly and 12 age-, gender-, and body mass index-matched healthy individuals were included in the study. Carotid intima–media thickness was dec...

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Bibliographic Details
Published in:Angiology 2012-10, Vol.63 (7), p.522-527
Main Authors: Boysan, S. N., Kantarci, F., Celik, O., Mihmanli, I., Gazioglu, N., Kadioglu, Pinar
Format: Article
Language:English
Subjects:
Acromegaly - diagnostic imaging
Acromegaly - drug therapy
Adult
Atherosclerosis (general aspects, experimental research)
Biological and medical sciences
Blood and lymphatic vessels
Body mass
Cardiology. Vascular system
Carotid Artery Diseases - diagnostic imaging
Carotid Artery Diseases - drug therapy
Carotid Artery, Internal - diagnostic imaging
Combined Modality Therapy
Delayed-Action Preparations
Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous
Echocardiography
Female
Follow-Up Studies
Growth factors
Hormones
Human Growth Hormone - blood
Humans
Insulin
Insulin Resistance - physiology
Insulin-Like Growth Factor I - metabolism
Male
Medical sciences
Middle Aged
Octreotide - adverse effects
Octreotide - therapeutic use
Risk factors
Tunica Intima - diagnostic imaging
Tunica Media - diagnostic imaging
Ultrasonography, Doppler
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Summary:We studied premature atherosclerosis with carotid Doppler ultrasonography in active acromegaly before and after treatment. Patients (n = 27) with active acromegaly and 12 age-, gender-, and body mass index-matched healthy individuals were included in the study. Carotid intima–media thickness was decreased significantly in the inactive group after treatment (median: 0.6 mm, interquartile range [IQR]: 0.55-0.80]) when compared with the active group (median: 0.9 mm [IQR: 0.75-1.15], P < .0001), but there was no significant difference between the inactive and control groups. There was a correlation between homeostasis model of assessment–insulin resistance (P = .01, r = .41) and growth hormone (GH; P < .0001, r = .46). In conclusion, premature atherosclerosis was demonstrated in active acromegaly patients probably as a consequence of insulin resistance and direct vascular effects of GH and/or insulin-like growth factor 1.
ISSN:0003-3197
1940-1574
DOI:10.1177/0003319711431879