MicroRNAs: A Light into the “Black Box” of Neuropediatric Diseases?

Although there have been tremendous advances in the diagnosis and treatment of pediatric brain diseases in the last few decades, the causes and pathogenesis of these diseases remain to be elucidated. Pediatric central nervous system (CNS) diseases create both short- and long-term impairments and dis...

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Bibliographic Details
Published in:Neuromolecular medicine 2012-12, Vol.14 (4), p.244-261
Main Authors: Omran, Ahmed, Elimam, Dalia, Shalaby, Sherien, Peng, Jing, Yin, Fei
Format: Article
Language:English
Subjects:
Age of Onset
Biomarkers
Biomedical and Life Sciences
Biomedicine
Brain
Brain Diseases - genetics
Brain Injuries - genetics
Central nervous system
Central Nervous System Neoplasms - genetics
Child
Child Development Disorders, Pervasive - genetics
Depressive Disorder - genetics
Development
Developmental Disabilities - genetics
Emotions
Epilepsy, Temporal Lobe - genetics
Etiology
Humans
Hypoxia-Ischemia, Brain - genetics
Internal Medicine
Meningitis, Bacterial - genetics
Mental disorders
MicroRNAs - genetics
MicroRNAs - physiology
MicroRNAs - therapeutic use
miRNA
Morbidity
Mortality
Muscular Dystrophies - genetics
Neural Tube Defects - genetics
Neurological diseases
Neurology
Neurosciences
Pediatrics
Review Paper
Reviews
Schizophrenia - genetics
Social interactions
Spinal Cord Injuries - genetics
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Summary:Although there have been tremendous advances in the diagnosis and treatment of pediatric brain diseases in the last few decades, the causes and pathogenesis of these diseases remain to be elucidated. Pediatric central nervous system (CNS) diseases create both short- and long-term impairments and disabilities and are therefore one of the leading causes for emotional, financial, and social burden to patients, their families, and their social network. The significant pediatric morbidity and mortality rates caused by CNS diseases call for equally significant efforts toward a better understanding of the etiology and nature of these disorders. Recent studies show the involvement of microRNAs (miRNAs) in various aspects of central nervous system development and neuropsychiatric diseases. This review focuses on the role of miRNAs in different pediatric neurological conditions. We emphasize the importance of microRNA-based research in combating pediatric neurological disorders. We believe this approach will result in novel therapies to secure normal development and prevent disabilities in the pediatric population.
ISSN:1535-1084
1559-1174
DOI:10.1007/s12017-012-8193-y