Heteroaromatic imidazo[1,2-a]pyridines synthesis from C-H/N-H oxidative cross-coupling/cyclization

A novel silver-mediated highly selective C-H/N-H oxidative cross-coupling/cyclization between 2-aminopyridines and terminal alkynes has been demonstrated. This approach provided a simple way to construct heteroaromatic imidazo[1,2-a]pyridines. By using this protocol, the marketed drug zolimidine (an...

Full description

Saved in:
Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2012-01, Vol.48 (90), p.11073-11075
Main Authors: He, Chuan, Hao, Jing, Xu, Huan, Mo, Yiping, Liu, Huiying, Han, Juanjuan, Lei, Aiwen
Format: Article
Language:English
Subjects:
Alkynes
Construction
Drugs
Synthesis
Terminals
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A novel silver-mediated highly selective C-H/N-H oxidative cross-coupling/cyclization between 2-aminopyridines and terminal alkynes has been demonstrated. This approach provided a simple way to construct heteroaromatic imidazo[1,2-a]pyridines. By using this protocol, the marketed drug zolimidine (antiulcer) could be synthesized easily.
ISSN:1359-7345
1364-548X
DOI:10.1039/c2cc35927h