Paclitaxel-Warfarin Interaction in Solution

Interactions of a water‐soluble paclitaxel‐polymer conjugate were investigated in aqueous buffer solutions and in the solid state in the presence of model proteins that are abundant in blood serum (bovine serum albumin and human serum albumin). Studies of the intrinsic fluorescence of albumins and e...

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Bibliographic Details
Published in:Macromolecular symposia 2006-10, Vol.242 (1), p.71-79
Main Authors: Wunderlich, Stefan, Zähres, Manfred, Jo, Byung-Wook, Hess, Michael
Format: Article
Language:English
Subjects:
Albumins
Applied sciences
Biological and medical sciences
Blood
Conjugates
Exact sciences and technology
Fluorescence
General pharmacology
interaction
Medical sciences
Organic polymers
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Physicochemistry of polymers
Properties and characterization
Proteins
Serum albumin
Solution and gel properties
Spectra
Warfarin
water-soluble paclitaxel
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Summary:Interactions of a water‐soluble paclitaxel‐polymer conjugate were investigated in aqueous buffer solutions and in the solid state in the presence of model proteins that are abundant in blood serum (bovine serum albumin and human serum albumin). Studies of the intrinsic fluorescence of albumins and extrinsic fluorescence of the albumin/warfarin complex and MALDI‐TOF spectra proved significant interactions of the drug conjugate with the model proteins and warfarin.
ISSN:1022-1360
1521-3900
DOI:10.1002/masy.200651012