Novel NiZr-based porous biomaterials: Synthesis and in vitro testing

• Published in: Chemical engineering journal (Lausanne, Switzerland : 1996) Switzerland : 1996), 2010-08, Vol.162 (1), p.406-414
• Main Authors: Manukyan, Khachatur, Amirkhanyan, Narine, Aydinyan, Sofiya, Danghyan, Vardan, Grigoryan, Ruzanna, Sarkisyan, Natalia, Gasparyan, Gennadi, Aroutiounian, Rouben, Kharatyan, Suren
• Format: Article
• Language: English
• Subjects: Additives; Applied sciences; Biomaterials; Biomedical materials; Chemical engineering; Combustion; Combustion synthesis; Cytotoxicity; Exact sciences and technology; Genotoxicity; In vitro testing; Nickel; NiZr biomaterial; Polytetrafluoroethylenes; Porosity; Surgical implants
• ISSN: 1385-8947; 1873-3212
• DOI: 10.1016/j.cej.2010.05.042

Novel porous NiZr-based potential biomaterials for orthopaedic application were developed using the combustion reaction in the Ni + Zr + additive mixtures. The effect of various additives (ZrH 2, CaCO 3, NH 4F and Teflon) on the combustion behaviour in the low-caloric Ni + Zr mixtures was investigated. To obtain molten porous NiZr-based product Teflon was chosen as an optimal additive. Combustion conditions of the Ni + Zr + Teflon mixtures depending on various factors were investigated. NiZr-based materials with 55–65% porosity and 50–550 μm pore sizes were obtained. The cyto- and genotoxicity of the materials was tested in vitro using HeLa and KCL-22 cell lines. After several extractions the obtained porous materials expressed no toxicity. Produced materials were non-genotoxic and had no effect on the cell proliferation.