Self-Diffusion of PEO-Modified Paclitaxel in Aqueous Solution: Hydrodynamic Properties

The anti‐cancer drug Paclitaxel has been hydrophilized by coupling with poly(ethylene oxide) through a self‐immolating linker to the polymer. The mobility of the functionalized polymer and of the amphiphilic drug‐modified polymer in D2O was studied by the temperature and concentration dependence of...

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Bibliographic Details
Published in:Macromolecular symposia. 2004-08, Vol.214 (1), p.351-360
Main Authors: Hess, Michael, Zähres, Manfred, Jo, Byung-Wook
Format: Article
Language:English
Subjects:
amphiphilic polymer
Coiling
Drugs
Fluid dynamics
Fluid flow
Hydrodynamics
Mathematical analysis
mobility
NMR spectroscopy
Oxides
pulse-gradient field NMR
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Summary:The anti‐cancer drug Paclitaxel has been hydrophilized by coupling with poly(ethylene oxide) through a self‐immolating linker to the polymer. The mobility of the functionalized polymer and of the amphiphilic drug‐modified polymer in D2O was studied by the temperature and concentration dependence of the long‐time self‐diffusion coefficients of the components. The technique applied was pulse‐gradient field NMR spectroscopy. The diffusivity of the molecules can be described in terms of the Einstein‐Sutherland and the Stokes‐Einstein equations. First results indicate that combining the drug with the polymer rather influences the rigidity parameter and the pair‐interaction in solution than the shape and the hydrodynamic radius of the polymer coil. Unexpectedly, micelle‐formation, although highly probable, was not observed within the concentration range investigated here.
ISSN:1022-1360
1521-3900
DOI:10.1002/masy.200451026