Organoselenium Drug with Antioxidant Activity and Free Radical Scavenging Capacity In Vitro

Organoselenum compounds have been reported to have a wide range of pharmacological properties. Amine-based diselenide, (Z)-N-(4-methylbenzylidene)-1-(2-((2-(1-((E)-4-methyl benzylideneamino)ethyl)phenyl)diselanyl)phenyl)ethanamine ethyl)phenyl) diselanyl) phenyl) ethylimino) methyl)phenol (compound...

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Bibliographic Details
Published in:Biological trace element research 2012-12, Vol.149 (3), p.399-404
Main Authors: Ibrahim, Mohammad, Hassan, Waseem, Deobald, Anna Maria, Braga, Antonio Luis, Rocha, Joao B. T
Format: Article
Language:English
Subjects:
Animals
antioxidant activity
Antioxidants
Antioxidants - chemistry
Antioxidants - pharmacology
Biochemistry
Biomedical and Life Sciences
Biotechnology
Biphenyl Compounds - chemistry
brain
drugs
free radical scavengers
Free radicals
Free Radicals - chemistry
Indexing in process
iron
Life Sciences
Lipid Peroxidation - drug effects
Lipids
Male
nitroprusside
Nutrition
Oncology
Organoselenium Compounds - chemistry
Organoselenium Compounds - pharmacology
Oxidative stress
Oxidative Stress - drug effects
Pharmacology
phenol
Phenols
Picrates - chemistry
Rats
Selenium
Thiobarbituric Acid Reactive Substances - metabolism
thiobarbituric acid-reactive substances
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Summary:Organoselenum compounds have been reported to have a wide range of pharmacological properties. Amine-based diselenide, (Z)-N-(4-methylbenzylidene)-1-(2-((2-(1-((E)-4-methyl benzylideneamino)ethyl)phenyl)diselanyl)phenyl)ethanamine ethyl)phenyl) diselanyl) phenyl) ethylimino) methyl)phenol (compound A), and diphenyl diselenide (PhSe)2 were screened for in vitro antioxidant activity. Compound A and (PhSe)2 were tested against sodium nitroprusside (SNP)- and Fe(II)-induced thiobarbituric acid-reactive species (TBARS) in rat brain homogenates. The radical scavenging activity was measured by 1,1-diphenyl-2-picrylhydrazyl assay. Both compounds A and (PhSe)2 decreased Fe(II)- and SNP-stimulated TBARS production in rat brain homogenates. Compound A exhibited the strongest antioxidant activity in the radical scavenging assay, although (PhSe)2, the simplest of the diaryl diselenide, presented no activity. In conclusion, the results of the present investigation indicated that compound A and (PhSe)2 had preventive effects against SNP- and Fe(II)-induced oxidative stress in rat brain homogenates. The amine group in the organic moiety dramatically changed the potency of amine-based diselenide.
ISSN:0163-4984
1559-0720
DOI:10.1007/s12011-012-9440-7