Cationic lipids activate intracellular signaling pathways

Cationic liposomes are commonly used as a transfection reagent for DNA, RNA or proteins and as a co-adjuvant of antigens for vaccination trials. A high density of positive charges close to cell surface is likely to be recognized as a signal of danger by cells or contribute to trigger cascades that a...

Full description

Saved in:
Bibliographic Details
Published in:Advanced drug delivery reviews 2012-12, Vol.64 (15), p.1749-1758
Main Authors: Lonez, Caroline, Vandenbranden, Michel, Ruysschaert, Jean-Marie
Format: Article
Language:English
Subjects:
Adjuvants
Adjuvants, Immunologic - administration & dosage
Animals
Antigens - immunology
Apoptosis
Apoptosis - drug effects
Cationic lipids
Cations
CD14
Drug Design
Humans
Immunostimulatory
Inflammation - chemically induced
Inflammation - pathology
Lipids - chemistry
Liposomes
MAPK
Signal Transduction - drug effects
Signaling
Transfection
Vaccines - immunology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Cationic liposomes are commonly used as a transfection reagent for DNA, RNA or proteins and as a co-adjuvant of antigens for vaccination trials. A high density of positive charges close to cell surface is likely to be recognized as a signal of danger by cells or contribute to trigger cascades that are classically activated by endogenous cationic compounds. The present review provides evidence that cationic liposomes activate several cellular pathways like pro-apoptotic and pro-inflammatory cascades. An improved knowledge of the relationship between the cationic lipid properties (nature of the lipid hydrophilic moieties, hydrocarbon tail, mode of organization) and the activation of these pathways opens the way to the use and design of cationic tailored for a specific application (e.g. for gene transport or as adjuvants). [Display omitted]
ISSN:0169-409X
1872-8294
DOI:10.1016/j.addr.2012.05.009