Vault particles: a new generation of delivery nanodevices

Graphical abstract Highlights ► Vault particles can be exploited in nanobiotechnology as drug delivery nanodevices. ► The structural information of vaults would serve as a guide for rational engineering. ► The dynamic structure of vaults may be controlled for manipulation of drug release. ► Engineer...

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Bibliographic Details
Published in:Current opinion in biotechnology 2012-12, Vol.23 (6), p.972-977
Main Authors: Casañas, Arnau, Guerra, Pablo, Fita, Ignasi, Verdaguer, Núria
Format: Article
Language:English
Subjects:
adaptability
biocompatibility
Biocompatible Materials - chemistry
Biocompatible Materials - metabolism
Biocompatible Materials - pharmacokinetics
drug carriers
Drug Delivery Systems - methods
Drugs
Dynamical systems
Dynamics
Humans
Internal Medicine
Nanocomposites
Nanomaterials
Nanomedicine - methods
Nanostructure
Organ Specificity
Self assembly
Vault Ribonucleoprotein Particles - chemistry
Vault Ribonucleoprotein Particles - metabolism
Vault Ribonucleoprotein Particles - pharmacokinetics
Vaults
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Summary:Graphical abstract Highlights ► Vault particles can be exploited in nanobiotechnology as drug delivery nanodevices. ► The structural information of vaults would serve as a guide for rational engineering. ► The dynamic structure of vaults may be controlled for manipulation of drug release. ► Engineered vaults allow specific cell targeting and controlled encapsulation.
ISSN:0958-1669
1879-0429
DOI:10.1016/j.copbio.2012.05.004