Cell-wall preparation containing poly-[gamma]-d-glutamate covalently linked to peptidoglycan, a straightforward extractable molecule, protects mice against experimental anthrax infection

Highlights *Bacillus anthracispeptidoglycan-linked poly-glutamate (GluPG) is a potent antigen. * GluPG+FIS partially protects mice against an encapsulatedB. anthracischallenge. * GluPG+PA fully protects mice against aB. anthracisvirulent strain challenge.

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Bibliographic Details
Published in:Vaccine 2012-12, Vol.31 (1), p.171-175
Main Authors: Candela, Thomas, Dumetz, Fabien, Tosi-Couture, Evelyne, Mock, Michèle, Goossens, Pierre L, Fouet, Agnès
Format: Article
Language:English
Subjects:
Antigens
Bacillus anthracis
Bacteriology
Experiments
Immunization
Infections
Laboratory animals
Microscopy
Proteins
Vaccines
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Description
Summary:Highlights *Bacillus anthracispeptidoglycan-linked poly-glutamate (GluPG) is a potent antigen. * GluPG+FIS partially protects mice against an encapsulatedB. anthracischallenge. * GluPG+PA fully protects mice against aB. anthracisvirulent strain challenge.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2012.10.071