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Dietary treatment in phenylketonuria does not lead to increased risk of obesity or metabolic syndrome
Little is known about the consequences of the special energy enriched diet used to treat patients with phenylketonuria (PKU) in terms of obesity and metabolic syndrome (MetSyn) development. To investigate the prevalence of overweight and obesity, and its consequences in terms of body composition and...
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| Published in: | Molecular genetics and metabolism 2012-12, Vol.107 (4), p.659-663 |
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| container_title | Molecular genetics and metabolism |
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| creator | Rocha, Júlio C. van Spronsen, Francjan J. Almeida, Manuela F. Soares, Gabriela Quelhas, Dulce Ramos, Elisabete Guimarães, João T. Borges, Nuno |
| description | Little is known about the consequences of the special energy enriched diet used to treat patients with phenylketonuria (PKU) in terms of obesity and metabolic syndrome (MetSyn) development.
To investigate the prevalence of overweight and obesity, and its consequences in terms of body composition and MetSyn in early treated patients with PKU compared to controls.
A sample of 89 patients with PKU (3–30y; 14.4±6.6y) and 79 controls (3–47y; 16.3±7.9y) were studied. In the fasted state, anthropometric, body composition, blood pressure and analytical parameters [amino acids, glucose, insulin, total and HDL-cholesterol (HDL-c), triglycerides (TG), high sensitivity c-reactive protein and uric acid] were performed. Data on dietary intake was collected. BMI was classified using WHO criteria, while the definition from International Diabetes Federation (IDF) was used for MetSyn.
Prevalence of overweight and obesity (32.6% vs. 24.1%; p=0.293), body fat percentage (22% vs. 23.1%, p=0.581) and central obesity (36.9% vs. 36.4%, p=0.999) were comparable to controls. Patients revealed a higher TG/HDL-c (p |
| doi_str_mv | 10.1016/j.ymgme.2012.10.006 |
| format | article |
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To investigate the prevalence of overweight and obesity, and its consequences in terms of body composition and MetSyn in early treated patients with PKU compared to controls.
A sample of 89 patients with PKU (3–30y; 14.4±6.6y) and 79 controls (3–47y; 16.3±7.9y) were studied. In the fasted state, anthropometric, body composition, blood pressure and analytical parameters [amino acids, glucose, insulin, total and HDL-cholesterol (HDL-c), triglycerides (TG), high sensitivity c-reactive protein and uric acid] were performed. Data on dietary intake was collected. BMI was classified using WHO criteria, while the definition from International Diabetes Federation (IDF) was used for MetSyn.
Prevalence of overweight and obesity (32.6% vs. 24.1%; p=0.293), body fat percentage (22% vs. 23.1%, p=0.581) and central obesity (36.9% vs. 36.4%, p=0.999) were comparable to controls. Patients revealed a higher TG/HDL-c (p<0.001). The prevalence of MetSyn was 1.5% and 6.1% in patients and controls, respectively. Patients and not controls with central obesity revealed a further significant increase in TG/HDL-c compared with those without central obesity (p=0.023).
Patients and controls were similar in terms of overweight and obesity, body composition and MetSyn. However, the dyslipidemia in patients with PKU in relation to overweight and obesity may help us trying to understand the course and the etiology of MetSyn not only in PKU but also in the general population.
► PKU patients and controls were similar in overweight and obesity prevalence. ► Body composition was not different in patients compared to controls. ► A trend to lower metabolic syndrome prevalence was found in patients with PKU.</description><identifier>ISSN: 1096-7192</identifier><identifier>EISSN: 1096-7206</identifier><identifier>DOI: 10.1016/j.ymgme.2012.10.006</identifier><identifier>PMID: 23137570</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adolescent ; Age Factors ; Body fat ; Case-Control Studies ; Child ; Cross-Sectional Studies ; Dyslipidemia ; Female ; Humans ; Male ; Metabolic syndrome ; Metabolic Syndrome - epidemiology ; Metabolic Syndrome - etiology ; Obesity ; Obesity - epidemiology ; Obesity - etiology ; Overweight ; Phenylketonuria ; Phenylketonurias - complications ; Phenylketonurias - diet therapy ; Prevalence ; Young Adult</subject><ispartof>Molecular genetics and metabolism, 2012-12, Vol.107 (4), p.659-663</ispartof><rights>2012 Elsevier Inc.</rights><rights>Copyright © 2012 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c497t-9a066767f6363023a5e3eef16ad6c1018bba71334faaf1daa2a882e4fcc7af293</citedby><cites>FETCH-LOGICAL-c497t-9a066767f6363023a5e3eef16ad6c1018bba71334faaf1daa2a882e4fcc7af293</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23137570$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rocha, Júlio C.</creatorcontrib><creatorcontrib>van Spronsen, Francjan J.</creatorcontrib><creatorcontrib>Almeida, Manuela F.</creatorcontrib><creatorcontrib>Soares, Gabriela</creatorcontrib><creatorcontrib>Quelhas, Dulce</creatorcontrib><creatorcontrib>Ramos, Elisabete</creatorcontrib><creatorcontrib>Guimarães, João T.</creatorcontrib><creatorcontrib>Borges, Nuno</creatorcontrib><title>Dietary treatment in phenylketonuria does not lead to increased risk of obesity or metabolic syndrome</title><title>Molecular genetics and metabolism</title><addtitle>Mol Genet Metab</addtitle><description>Little is known about the consequences of the special energy enriched diet used to treat patients with phenylketonuria (PKU) in terms of obesity and metabolic syndrome (MetSyn) development.
To investigate the prevalence of overweight and obesity, and its consequences in terms of body composition and MetSyn in early treated patients with PKU compared to controls.
A sample of 89 patients with PKU (3–30y; 14.4±6.6y) and 79 controls (3–47y; 16.3±7.9y) were studied. In the fasted state, anthropometric, body composition, blood pressure and analytical parameters [amino acids, glucose, insulin, total and HDL-cholesterol (HDL-c), triglycerides (TG), high sensitivity c-reactive protein and uric acid] were performed. Data on dietary intake was collected. BMI was classified using WHO criteria, while the definition from International Diabetes Federation (IDF) was used for MetSyn.
Prevalence of overweight and obesity (32.6% vs. 24.1%; p=0.293), body fat percentage (22% vs. 23.1%, p=0.581) and central obesity (36.9% vs. 36.4%, p=0.999) were comparable to controls. Patients revealed a higher TG/HDL-c (p<0.001). The prevalence of MetSyn was 1.5% and 6.1% in patients and controls, respectively. Patients and not controls with central obesity revealed a further significant increase in TG/HDL-c compared with those without central obesity (p=0.023).
Patients and controls were similar in terms of overweight and obesity, body composition and MetSyn. However, the dyslipidemia in patients with PKU in relation to overweight and obesity may help us trying to understand the course and the etiology of MetSyn not only in PKU but also in the general population.
► PKU patients and controls were similar in overweight and obesity prevalence. ► Body composition was not different in patients compared to controls. ► A trend to lower metabolic syndrome prevalence was found in patients with PKU.</description><subject>Adolescent</subject><subject>Age Factors</subject><subject>Body fat</subject><subject>Case-Control Studies</subject><subject>Child</subject><subject>Cross-Sectional Studies</subject><subject>Dyslipidemia</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Metabolic syndrome</subject><subject>Metabolic Syndrome - epidemiology</subject><subject>Metabolic Syndrome - etiology</subject><subject>Obesity</subject><subject>Obesity - epidemiology</subject><subject>Obesity - etiology</subject><subject>Overweight</subject><subject>Phenylketonuria</subject><subject>Phenylketonurias - complications</subject><subject>Phenylketonurias - diet therapy</subject><subject>Prevalence</subject><subject>Young Adult</subject><issn>1096-7192</issn><issn>1096-7206</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><recordid>eNqNkctOBCEQRYnR-P4CE8PSzYw8eqB74cL4Tkzc6JrQUChjdzMCY9J_L-OoS3UFqZy6laqD0BElU0qoOJ1Px_65hykjlJXKlBCxgXYpacREMiI2v_-0YTtoL6U5IZTOmmob7TBOuZxJsovg0kPWccQ5gs49DBn7AS9eYBi7V8hhWEavsQ2Q8BAy7kBbnENhTOETWBx9esXB4dBC8nnEIeK-JLah8wancbAx9HCAtpzuEhx-vfvo6frq8eJ2cv9wc3dxfj8xVSPzpNFECCmkE1xwwrieAQdwVGgrTNm5blstKeeV09pRqzXTdc2gcsZI7VjD99HJOncRw9sSUla9Twa6Tg8QlklRJpnkpKqr_6GMN5X8G6W1aFiJXaXyNWpiSCmCU4vo-3JfRYlaWVNz9WlNraytisVa6Tr-GrBse7A_Pd-aCnC2BqAc791DVMl4GAxYH8FkZYP_dcAHscuqVQ</recordid><startdate>20121201</startdate><enddate>20121201</enddate><creator>Rocha, Júlio C.</creator><creator>van Spronsen, Francjan J.</creator><creator>Almeida, Manuela F.</creator><creator>Soares, Gabriela</creator><creator>Quelhas, Dulce</creator><creator>Ramos, Elisabete</creator><creator>Guimarães, João T.</creator><creator>Borges, Nuno</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TS</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>20121201</creationdate><title>Dietary treatment in phenylketonuria does not lead to increased risk of obesity or metabolic syndrome</title><author>Rocha, Júlio C. ; van Spronsen, Francjan J. ; Almeida, Manuela F. ; Soares, Gabriela ; Quelhas, Dulce ; Ramos, Elisabete ; Guimarães, João T. ; Borges, Nuno</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c497t-9a066767f6363023a5e3eef16ad6c1018bba71334faaf1daa2a882e4fcc7af293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adolescent</topic><topic>Age Factors</topic><topic>Body fat</topic><topic>Case-Control Studies</topic><topic>Child</topic><topic>Cross-Sectional Studies</topic><topic>Dyslipidemia</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Metabolic syndrome</topic><topic>Metabolic Syndrome - epidemiology</topic><topic>Metabolic Syndrome - etiology</topic><topic>Obesity</topic><topic>Obesity - epidemiology</topic><topic>Obesity - etiology</topic><topic>Overweight</topic><topic>Phenylketonuria</topic><topic>Phenylketonurias - complications</topic><topic>Phenylketonurias - diet therapy</topic><topic>Prevalence</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rocha, Júlio C.</creatorcontrib><creatorcontrib>van Spronsen, Francjan J.</creatorcontrib><creatorcontrib>Almeida, Manuela F.</creatorcontrib><creatorcontrib>Soares, Gabriela</creatorcontrib><creatorcontrib>Quelhas, Dulce</creatorcontrib><creatorcontrib>Ramos, Elisabete</creatorcontrib><creatorcontrib>Guimarães, João T.</creatorcontrib><creatorcontrib>Borges, Nuno</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Physical Education Index</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Molecular genetics and metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rocha, Júlio C.</au><au>van Spronsen, Francjan J.</au><au>Almeida, Manuela F.</au><au>Soares, Gabriela</au><au>Quelhas, Dulce</au><au>Ramos, Elisabete</au><au>Guimarães, João T.</au><au>Borges, Nuno</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dietary treatment in phenylketonuria does not lead to increased risk of obesity or metabolic syndrome</atitle><jtitle>Molecular genetics and metabolism</jtitle><addtitle>Mol Genet Metab</addtitle><date>2012-12-01</date><risdate>2012</risdate><volume>107</volume><issue>4</issue><spage>659</spage><epage>663</epage><pages>659-663</pages><issn>1096-7192</issn><eissn>1096-7206</eissn><abstract>Little is known about the consequences of the special energy enriched diet used to treat patients with phenylketonuria (PKU) in terms of obesity and metabolic syndrome (MetSyn) development.
To investigate the prevalence of overweight and obesity, and its consequences in terms of body composition and MetSyn in early treated patients with PKU compared to controls.
A sample of 89 patients with PKU (3–30y; 14.4±6.6y) and 79 controls (3–47y; 16.3±7.9y) were studied. In the fasted state, anthropometric, body composition, blood pressure and analytical parameters [amino acids, glucose, insulin, total and HDL-cholesterol (HDL-c), triglycerides (TG), high sensitivity c-reactive protein and uric acid] were performed. Data on dietary intake was collected. BMI was classified using WHO criteria, while the definition from International Diabetes Federation (IDF) was used for MetSyn.
Prevalence of overweight and obesity (32.6% vs. 24.1%; p=0.293), body fat percentage (22% vs. 23.1%, p=0.581) and central obesity (36.9% vs. 36.4%, p=0.999) were comparable to controls. Patients revealed a higher TG/HDL-c (p<0.001). The prevalence of MetSyn was 1.5% and 6.1% in patients and controls, respectively. Patients and not controls with central obesity revealed a further significant increase in TG/HDL-c compared with those without central obesity (p=0.023).
Patients and controls were similar in terms of overweight and obesity, body composition and MetSyn. However, the dyslipidemia in patients with PKU in relation to overweight and obesity may help us trying to understand the course and the etiology of MetSyn not only in PKU but also in the general population.
► PKU patients and controls were similar in overweight and obesity prevalence. ► Body composition was not different in patients compared to controls. ► A trend to lower metabolic syndrome prevalence was found in patients with PKU.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>23137570</pmid><doi>10.1016/j.ymgme.2012.10.006</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
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| ispartof | Molecular genetics and metabolism, 2012-12, Vol.107 (4), p.659-663 |
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| source | Elsevier |
| subjects | Adolescent Age Factors Body fat Case-Control Studies Child Cross-Sectional Studies Dyslipidemia Female Humans Male Metabolic syndrome Metabolic Syndrome - epidemiology Metabolic Syndrome - etiology Obesity Obesity - epidemiology Obesity - etiology Overweight Phenylketonuria Phenylketonurias - complications Phenylketonurias - diet therapy Prevalence Young Adult |
| title | Dietary treatment in phenylketonuria does not lead to increased risk of obesity or metabolic syndrome |
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