Production and immunogenicity of chimeric virus-like particles containing porcine reproductive and respiratory syndrome virus GP5 protein

Highlights ► We develop chimeric virus-like particles (VLPs) vaccine candidate for PRRSV protection. ► The chimeric VLPs are composed of influenza virus M1 and PRRSV GP5 fused to influenza virus NA. ► Immunization of mice with the VLPs can stimulate immune responses comparable to killed PRRSV.

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Bibliographic Details
Published in:Vaccine 2012-11, Vol.30 (49), p.7072-7077
Main Authors: Wang, Wei, Chen, Xiaochun, Xue, Chunyi, Du, Yichao, Lv, Lishan, Liu, Qiliang, Li, Xiaoming, Ma, Yun, Shen, Huifang, Cao, Yongchang
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animals
Antibodies
Antibodies, Viral - blood
cell-mediated immunity
Chimeric virus-like particles
chimerism
Clinical trials
Cloning
Data processing
Economics
Fusion protein
Genes
Genomes
Hogs
Immune response
Immune system
Immunization
Immunogenicity
inactivated vaccines
industry
Infection
Infections
Influenza
Influenza A virus
Influenza virus
Injections, Intramuscular
Lymphocytes - immunology
Mice
Mice, Inbred BALB C
Neuraminidase - genetics
Porcine reproductive and respiratory syndrome virus
Porcine respiratory and reproductive syndrome virus
Porcine respiratory and reproductive syndrome virus - genetics
Porcine respiratory and reproductive syndrome virus - immunology
Proteins
Recombinant Fusion Proteins - genetics
Recombinant Fusion Proteins - immunology
swine
Swine flu
Transmembrane domains
vaccination
vaccine development
Vaccines
Vaccines, Synthetic - administration & dosage
Vaccines, Synthetic - genetics
Vaccines, Synthetic - immunology
Vaccines, Virus-Like Particle - administration & dosage
Vaccines, Virus-Like Particle - genetics
Vaccines, Virus-Like Particle - immunology
Viral Envelope Proteins - genetics
Viral Envelope Proteins - immunology
Viral Matrix Proteins - genetics
Viral Proteins - genetics
virus-like particle vaccines
Virus-like particles
viruses
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Description
Summary:Highlights ► We develop chimeric virus-like particles (VLPs) vaccine candidate for PRRSV protection. ► The chimeric VLPs are composed of influenza virus M1 and PRRSV GP5 fused to influenza virus NA. ► Immunization of mice with the VLPs can stimulate immune responses comparable to killed PRRSV.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2012.09.048