Genetic insights in Alzheimer's disease

Summary In the search for new genes in Alzheimer's disease, classic linkage-based and candidate-gene-based association studies have been supplanted by exome sequencing, genome-wide sequencing (for mendelian forms of Alzheimer's disease), and genome-wide association studies (for non-mendeli...

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Bibliographic Details
Published in:Lancet neurology 2013, Vol.12 (1), p.92-104
Main Authors: Bettens, Karolien, PhD, Sleegers, Kristel, PhD, Van Broeckhoven, Christine, Prof
Format: Article
Language:English
Subjects:
Alzheimer Disease - diagnosis
Alzheimer Disease - epidemiology
Alzheimer Disease - genetics
Alzheimer's disease
Animals
Genetic Linkage - genetics
Genetic Predisposition to Disease - epidemiology
Genetic Predisposition to Disease - genetics
Genome-Wide Association Study - trends
Humans
Neurology
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Summary:Summary In the search for new genes in Alzheimer's disease, classic linkage-based and candidate-gene-based association studies have been supplanted by exome sequencing, genome-wide sequencing (for mendelian forms of Alzheimer's disease), and genome-wide association studies (for non-mendelian forms). The identification of new susceptibility genes has opened new avenues for exploration of the underlying disease mechanisms. In addition to detecting novel risk factors in large samples, next-generation sequencing approaches can deliver novel insights with even small numbers of patients. The shift in focus towards translational studies and sequencing of individual patients places each patient's biomaterials as the central unit of genetic studies. The notional shift needed to make the patient central to genetic studies will necessitate strong collaboration and input from clinical neurologists.
ISSN:1474-4422
1474-4465
DOI:10.1016/S1474-4422(12)70259-4