Three Fatal Intoxications Due to Methylone

• Published in: Journal of analytical toxicology 2012-07, Vol.36 (6), p.444-451
• Main Authors: Pearson, Julia M., Hargraves, Tiffanie L., Hair, Laura S., Massucci, Charles J., Clinton Frazee, C., Garg, Uttam, Pietak, B. Robert
• Format: Article
• Language: English
• Subjects: Acidosis - etiology; Adult; Body temperature; Calcium; Central Nervous System Stimulants - blood; Central Nervous System Stimulants - toxicity; Clotting; Creatine kinase; Creatinine; Disseminated intravascular coagulation; Fatal Outcome; Female; Fever - etiology; Glucose; Humans; Intoxication; Lactic acid; Liver; Male; Metabolic acidosis; Methamphetamine - analogs & derivatives; Methamphetamine - blood; Methamphetamine - toxicity; myoglobin; Peripheral blood; pH effects; Psychoses, Substance-Induced - physiopathology; Psychoses, Substance-Induced - therapy; Quantitation; Renal failure; Seizures - etiology; Street Drugs - blood; Street Drugs - toxicity; Sympathomimetics; Toxicity; transaminase; Young Adult
• ISSN: 0146-4760; 1945-2403
• DOI: 10.1093/jat/bks043

We present three fatal intoxications of methylone, a cathinone derivative. Blood was analyzed with a routine alkaline liquid-liquid extraction and analyzed by gas chromatography coupled with a mass spectrometer (GC-MS). Methylone was identified by a full scan mass spectral comparison to an analytical standard of methylone. For a definitive and conclusive confirmation and quantitation, methylone was also derivatized with heptafluorobutyric anhydride and analyzed by GC-MS. In all three fatalities, the deceased exhibited seizure-like activity and elevated body temperatures (103.9, 105.9 and 107°F) before death. Two of the three cases also exhibited metabolic acidosis. One of the three cases had prolonged treatment and hospitalization before death with symptoms similar to sympathomimetic toxicity, including metabolic acidosis, rhabdomyolysis, acute renal failure and disseminated intravascular coagulation. The laboratory results for this patient over the 24 h period of hospitalization were significant for increased lactate, liver transaminases, creatinine, myoglobin, creatine kinase and clotting times, and decreased pH, glucose and calcium. Peripheral blood methylone concentrations in the three fatal cases were 0.84, 3.3 and 0.56 mg/L. In conlusion, peripheral blood methylone concentrations in excess of 0.5 mg/L may result in death due to its toxic properties, which can include elevated body temperature and other sympathomimetic-like symptoms.