From In Situ to In Vivo: An In Situ Click-Chemistry-Derived Carbonic Anhydrase II Imaging Agent for Positron Emission Tomography

CA II makes a good PET: Discovering positron emission tomography (PET) probes with high target affinities is challenging. PET probe discovery using in situ click chemistry uses 19F‐bearing fragments as 18F surrogates. This ensures that the lead hits and PET probes have equivalent chemical or biologi...

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Bibliographic Details
Published in:ChemMedChem 2013-01, Vol.8 (1), p.43-48
Main Authors: Mocharla, Vani P., Walsh, Joseph C., Padgett, Henry C., Su, Helen, Fueger, Barbara, Weber, Wolfgang A., Czernin, Johannes, Kolb, Hartmuth C.
Format: Article
Language:English
Subjects:
Animals
Carbonic Anhydrase II - analysis
carbonic anhydrases
click chemistry
Click Chemistry - methods
Erythrocytes - enzymology
Fluorine Radioisotopes - analysis
Humans
Mice
Mice, SCID
molecular imaging
positron emission tomography
Positron-Emission Tomography - methods
triazoles
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Description
Summary:CA II makes a good PET: Discovering positron emission tomography (PET) probes with high target affinities is challenging. PET probe discovery using in situ click chemistry uses 19F‐bearing fragments as 18F surrogates. This ensures that the lead hits and PET probes have equivalent chemical or biological characteristics, making PET probe discovery predictable and reliable.
ISSN:1860-7179
1860-7187
DOI:10.1002/cmdc.201200466