The effects of Sophora angustifolia and other natural plant extracts on melanogenesis and melanin transfer in human skin cells

Skin pigmentation is a multistep process of melanin synthesis by melanocytes, its transfer to recipient keratinocytes and its degradation. As dyspigmentation is a prominent marker of skin ageing, novel effective agents that modulate pigmentation safely are being sought for both clinical and cosmetic...

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Bibliographic Details
Published in:Experimental dermatology 2013-01, Vol.22 (1), p.67-69
Main Authors: Singh, Suman K., Baker, Richard, Wibawa, Judata I. D., Bell, Mike, Tobin, Desmond J.
Format: Article
Language:English
Subjects:
1-Methyl-3-isobutylxanthine - pharmacology
Actinidia
age-spots
Ascorbic Acid - pharmacology
Cells, Cultured
Coculture Techniques
filopodia
Fruit
Humans
Hydroquinones - pharmacology
hyperpigmentation
Keratinocytes - drug effects
Keratinocytes - metabolism
Melanins - biosynthesis
Melanins - metabolism
melanocytes
Melanocytes - drug effects
Melanocytes - metabolism
Microscopy, Confocal
Morus
Niacinamide - pharmacology
Plant Extracts - pharmacology
Plant Leaves
Plant Roots
solar lentigines
Sophora
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Summary:Skin pigmentation is a multistep process of melanin synthesis by melanocytes, its transfer to recipient keratinocytes and its degradation. As dyspigmentation is a prominent marker of skin ageing, novel effective agents that modulate pigmentation safely are being sought for both clinical and cosmetic use. Here, a number of plant extracts were examined for their effect on melanogenesis (by melanin assay and Western blotting) and melanin transfer (by confocal immunomicroscopy of gp100‐positive melanin granules in cocultures and by SEM analysis of filopodia), in human melanocytes and in cocultures with phototype‐matched normal adult epidermal keratinocytes. Mulberry, Kiwi and Sophora extracts were assessed against isobutylmethylxanthine, hydroquinone, vitamin C and niacinamide. Compared with unstimulated control, all extracts significantly reduced melanogenesis in human melanoma cells and normal adult epidermal melanocytes. These extracts also reduced melanin transfer and reduced filopodia expression on melanocytes, similar to hydroquinone and niacinamide, indicating their effectiveness as multimode pigmentation actives.
ISSN:0906-6705
1600-0625
DOI:10.1111/exd.12061