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Hypoglycaemic episodes and risk of dementia in diabetes mellitus: 7‐year follow‐up study

Objective We investigated the risk of dementia in patients with type 2 diabetes with or without prior hypoglycaemic episodes. Subjects and Setting One million subjects randomly selected from the National Health Insurance Research Database, Taiwan. Results A total of 15 404 diabetic subjects without...

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Bibliographic Details
Published in:Journal of internal medicine 2013-01, Vol.273 (1), p.102-110
Main Authors: Lin, C.‐H., Sheu, W. H.‐H.
Format: Article
Language:English
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Summary:Objective We investigated the risk of dementia in patients with type 2 diabetes with or without prior hypoglycaemic episodes. Subjects and Setting One million subjects randomly selected from the National Health Insurance Research Database, Taiwan. Results A total of 15 404 diabetic subjects without prior dementia and a mean age of 64.2 years were enrolled in the study. About 2% (n = 289) of participants had at least one episode of hypoglycaemia in a 3‐year period; these subjects were older and more likely to be women and also had higher rates of insulin use and comorbidities compared to those without hypoglycaemia. During a total of 7 years of follow‐up (mean and median follow‐up, 3.8 and 4.8 years, respectively), 1106 patients with diabetes (7.2%) developed dementia. The incidence rate of dementia was higher in diabetic subjects with [29.9 per 1000 person‐years (95% CI 22.1–39.2)] compared to those without [11.1 per 1000 person‐years (95% CI 10.3–11.8)] hypoglycaemic episodes. The crude rate ratio (RR) and age‐ and gender‐adjusted RR values for dementia were 2.76 (95% CI 2.06–3.70, P 
ISSN:0954-6820
1365-2796
DOI:10.1111/joim.12000