Oxidative stress and liver monooxygenase function after heart valve surgery

Background and objectives: this prospective study was carried out to evaluate oxidative stress and liver monooxygenase function after cardiac surgery in patients with acquired valvular heart disease. Methods: 97 patients were studied. Oxidative stress was quantified with malondialdehyde, coupled tri...

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Published in:Asian cardiovascular & thoracic annals 2012-12, Vol.20 (6), p.675-681
Main Authors: Nepomniashchikh, Valery A, Lomivorotov, Vladimir V, Deryagin, Michael N, Lomivorotov, Vladimir N, Kniazkova, Lyubov G, Fominskiy, Evgeniy V, Novikov, Maxim A
Format: Article
Language:English
Subjects:
Female
Heart Valve Diseases - surgery
Heart Valve Prosthesis Implantation
Humans
Liver - enzymology
Male
Middle Aged
Mixed Function Oxygenases - metabolism
Oxidative Stress
Postoperative Period
Prospective Studies
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Summary:Background and objectives: this prospective study was carried out to evaluate oxidative stress and liver monooxygenase function after cardiac surgery in patients with acquired valvular heart disease. Methods: 97 patients were studied. Oxidative stress was quantified with malondialdehyde, coupled trienes, hepatocuprein, and catalase activity. Liver monooxygenase function was evaluated with antipyrine pharmacokinetics. For statistical analyses, the Dunnett test and Pearson’s correlation coefficient were used. Results: on the 1st–2nd postoperative days, high lipid peroxidation activation (malondialdehyde: 9.6 ± 2.7 vs. 6.9 ± 2.0 nmol·mL−1, p 
ISSN:0218-4923
1816-5370
DOI:10.1177/0218492312444623