Oxidative stress and liver monooxygenase function after heart valve surgery

Background and objectives: this prospective study was carried out to evaluate oxidative stress and liver monooxygenase function after cardiac surgery in patients with acquired valvular heart disease. Methods: 97 patients were studied. Oxidative stress was quantified with malondialdehyde, coupled tri...

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Published in:Asian cardiovascular & thoracic annals 2012-12, Vol.20 (6), p.675-681
Main Authors: Nepomniashchikh, Valery A, Lomivorotov, Vladimir V, Deryagin, Michael N, Lomivorotov, Vladimir N, Kniazkova, Lyubov G, Fominskiy, Evgeniy V, Novikov, Maxim A
Format: Article
Language:English
Subjects:
Female
Heart Valve Diseases - surgery
Heart Valve Prosthesis Implantation
Humans
Liver - enzymology
Male
Middle Aged
Mixed Function Oxygenases - metabolism
Oxidative Stress
Postoperative Period
Prospective Studies
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cited_by cdi_FETCH-LOGICAL-c252t-857ca0d3c39aa15b3469455fff0034f07992825e464142ff011cb74af88eaff03
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container_issue 6
container_start_page 675
container_title Asian cardiovascular & thoracic annals
container_volume 20
creator Nepomniashchikh, Valery A
Lomivorotov, Vladimir V
Deryagin, Michael N
Lomivorotov, Vladimir N
Kniazkova, Lyubov G
Fominskiy, Evgeniy V
Novikov, Maxim A
description Background and objectives: this prospective study was carried out to evaluate oxidative stress and liver monooxygenase function after cardiac surgery in patients with acquired valvular heart disease. Methods: 97 patients were studied. Oxidative stress was quantified with malondialdehyde, coupled trienes, hepatocuprein, and catalase activity. Liver monooxygenase function was evaluated with antipyrine pharmacokinetics. For statistical analyses, the Dunnett test and Pearson’s correlation coefficient were used. Results: on the 1st–2nd postoperative days, high lipid peroxidation activation (malondialdehyde: 9.6 ± 2.7 vs. 6.9 ± 2.0 nmol·mL−1, p 
doi_str_mv 10.1177/0218492312444623
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Methods: 97 patients were studied. Oxidative stress was quantified with malondialdehyde, coupled trienes, hepatocuprein, and catalase activity. Liver monooxygenase function was evaluated with antipyrine pharmacokinetics. For statistical analyses, the Dunnett test and Pearson’s correlation coefficient were used. Results: on the 1st–2nd postoperative days, high lipid peroxidation activation (malondialdehyde: 9.6 ± 2.7 vs. 6.9 ± 2.0 nmol·mL−1, p &lt; 0.05) and a significant decrease in liver monooxygenase function (antipyrine clearance: 18.3 ± 11.1 vs. 39.0 ± 18.9 mL·kg−1·h−1, p &lt; 0.05) were revealed. On the 3rd–4th and 11th–12th postoperative days, the intensity of oxidative stress decreased and monooxygenase function returned to baseline (antipyrine clearance: 45.6 ± 17.9 vs. 39.0 ± 18.9 mL·kg−1·h−1). The analysis showed a negative relationship between oxidative stress and liver monooxygenase function. Conclusion: patients undergoing surgery for acquired valvular heart disease have considerable oxidative stress and a decrease in liver monooxygenase function on the 1st–2nd postoperative days. Activation of lipid peroxidation is one of the main reasons for suppression of microsomal monooxygenases activity. A slowdown of liver microsomal oxidation might change the pharmacokinetic response of patients under drug therapy.</description><identifier>ISSN: 0218-4923</identifier><identifier>EISSN: 1816-5370</identifier><identifier>DOI: 10.1177/0218492312444623</identifier><identifier>PMID: 23284109</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Female ; Heart Valve Diseases - surgery ; Heart Valve Prosthesis Implantation ; Humans ; Liver - enzymology ; Male ; Middle Aged ; Mixed Function Oxygenases - metabolism ; Oxidative Stress ; Postoperative Period ; Prospective Studies</subject><ispartof>Asian cardiovascular &amp; thoracic annals, 2012-12, Vol.20 (6), p.675-681</ispartof><rights>The Author(s) 2012 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c252t-857ca0d3c39aa15b3469455fff0034f07992825e464142ff011cb74af88eaff03</citedby><cites>FETCH-LOGICAL-c252t-857ca0d3c39aa15b3469455fff0034f07992825e464142ff011cb74af88eaff03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924,79135</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23284109$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nepomniashchikh, Valery A</creatorcontrib><creatorcontrib>Lomivorotov, Vladimir V</creatorcontrib><creatorcontrib>Deryagin, Michael N</creatorcontrib><creatorcontrib>Lomivorotov, Vladimir N</creatorcontrib><creatorcontrib>Kniazkova, Lyubov G</creatorcontrib><creatorcontrib>Fominskiy, Evgeniy V</creatorcontrib><creatorcontrib>Novikov, Maxim A</creatorcontrib><title>Oxidative stress and liver monooxygenase function after heart valve surgery</title><title>Asian cardiovascular &amp; thoracic annals</title><addtitle>Asian Cardiovasc Thorac Ann</addtitle><description>Background and objectives: this prospective study was carried out to evaluate oxidative stress and liver monooxygenase function after cardiac surgery in patients with acquired valvular heart disease. Methods: 97 patients were studied. Oxidative stress was quantified with malondialdehyde, coupled trienes, hepatocuprein, and catalase activity. Liver monooxygenase function was evaluated with antipyrine pharmacokinetics. For statistical analyses, the Dunnett test and Pearson’s correlation coefficient were used. Results: on the 1st–2nd postoperative days, high lipid peroxidation activation (malondialdehyde: 9.6 ± 2.7 vs. 6.9 ± 2.0 nmol·mL−1, p &lt; 0.05) and a significant decrease in liver monooxygenase function (antipyrine clearance: 18.3 ± 11.1 vs. 39.0 ± 18.9 mL·kg−1·h−1, p &lt; 0.05) were revealed. On the 3rd–4th and 11th–12th postoperative days, the intensity of oxidative stress decreased and monooxygenase function returned to baseline (antipyrine clearance: 45.6 ± 17.9 vs. 39.0 ± 18.9 mL·kg−1·h−1). The analysis showed a negative relationship between oxidative stress and liver monooxygenase function. Conclusion: patients undergoing surgery for acquired valvular heart disease have considerable oxidative stress and a decrease in liver monooxygenase function on the 1st–2nd postoperative days. Activation of lipid peroxidation is one of the main reasons for suppression of microsomal monooxygenases activity. A slowdown of liver microsomal oxidation might change the pharmacokinetic response of patients under drug therapy.</description><subject>Female</subject><subject>Heart Valve Diseases - surgery</subject><subject>Heart Valve Prosthesis Implantation</subject><subject>Humans</subject><subject>Liver - enzymology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mixed Function Oxygenases - metabolism</subject><subject>Oxidative Stress</subject><subject>Postoperative Period</subject><subject>Prospective Studies</subject><issn>0218-4923</issn><issn>1816-5370</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><recordid>eNp1UDtPwzAQthCIhsLOhDKyBHx-JM6IKl6iUheYo2til1RJXOykav89jloYkJhO330P3X2EXAO9A8iye8pAiZxxYEKIlPETEoGCNJE8o6ckGulk5Cfkwvs1pZQDV-dkwjhTAmgekbfFrq6wr7c69r3T3sfYVXETsItb21m72690h17HZujKvrZdjKYP5KdG18dbbEbn4Fba7S_JmcHG66vjnJKPp8f32UsyXzy_zh7mSckk6xMlsxJpxUueI4JccpHmQkpjTLhPGJrlOVNMapEKECxsAcplJtAopTFAPiW3h9yNs1-D9n3R1r7UTYOdtoMvgGUcUskVC1J6kJbOeu-0KTaubtHtC6DFWGHxt8JguTmmD8tWV7-Gn86CIDkIPK50sbaD68K3_wd-A7hxeHc</recordid><startdate>201212</startdate><enddate>201212</enddate><creator>Nepomniashchikh, Valery A</creator><creator>Lomivorotov, Vladimir V</creator><creator>Deryagin, Michael N</creator><creator>Lomivorotov, Vladimir N</creator><creator>Kniazkova, Lyubov G</creator><creator>Fominskiy, Evgeniy V</creator><creator>Novikov, Maxim A</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201212</creationdate><title>Oxidative stress and liver monooxygenase function after heart valve surgery</title><author>Nepomniashchikh, Valery A ; Lomivorotov, Vladimir V ; Deryagin, Michael N ; Lomivorotov, Vladimir N ; Kniazkova, Lyubov G ; Fominskiy, Evgeniy V ; Novikov, Maxim A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c252t-857ca0d3c39aa15b3469455fff0034f07992825e464142ff011cb74af88eaff03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Female</topic><topic>Heart Valve Diseases - surgery</topic><topic>Heart Valve Prosthesis Implantation</topic><topic>Humans</topic><topic>Liver - enzymology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mixed Function Oxygenases - metabolism</topic><topic>Oxidative Stress</topic><topic>Postoperative Period</topic><topic>Prospective Studies</topic><toplevel>online_resources</toplevel><creatorcontrib>Nepomniashchikh, Valery A</creatorcontrib><creatorcontrib>Lomivorotov, Vladimir V</creatorcontrib><creatorcontrib>Deryagin, Michael N</creatorcontrib><creatorcontrib>Lomivorotov, Vladimir N</creatorcontrib><creatorcontrib>Kniazkova, Lyubov G</creatorcontrib><creatorcontrib>Fominskiy, Evgeniy V</creatorcontrib><creatorcontrib>Novikov, Maxim A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Asian cardiovascular &amp; thoracic annals</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nepomniashchikh, Valery A</au><au>Lomivorotov, Vladimir V</au><au>Deryagin, Michael N</au><au>Lomivorotov, Vladimir N</au><au>Kniazkova, Lyubov G</au><au>Fominskiy, Evgeniy V</au><au>Novikov, Maxim A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Oxidative stress and liver monooxygenase function after heart valve surgery</atitle><jtitle>Asian cardiovascular &amp; thoracic annals</jtitle><addtitle>Asian Cardiovasc Thorac Ann</addtitle><date>2012-12</date><risdate>2012</risdate><volume>20</volume><issue>6</issue><spage>675</spage><epage>681</epage><pages>675-681</pages><issn>0218-4923</issn><eissn>1816-5370</eissn><abstract>Background and objectives: this prospective study was carried out to evaluate oxidative stress and liver monooxygenase function after cardiac surgery in patients with acquired valvular heart disease. Methods: 97 patients were studied. Oxidative stress was quantified with malondialdehyde, coupled trienes, hepatocuprein, and catalase activity. Liver monooxygenase function was evaluated with antipyrine pharmacokinetics. For statistical analyses, the Dunnett test and Pearson’s correlation coefficient were used. Results: on the 1st–2nd postoperative days, high lipid peroxidation activation (malondialdehyde: 9.6 ± 2.7 vs. 6.9 ± 2.0 nmol·mL−1, p &lt; 0.05) and a significant decrease in liver monooxygenase function (antipyrine clearance: 18.3 ± 11.1 vs. 39.0 ± 18.9 mL·kg−1·h−1, p &lt; 0.05) were revealed. On the 3rd–4th and 11th–12th postoperative days, the intensity of oxidative stress decreased and monooxygenase function returned to baseline (antipyrine clearance: 45.6 ± 17.9 vs. 39.0 ± 18.9 mL·kg−1·h−1). The analysis showed a negative relationship between oxidative stress and liver monooxygenase function. Conclusion: patients undergoing surgery for acquired valvular heart disease have considerable oxidative stress and a decrease in liver monooxygenase function on the 1st–2nd postoperative days. Activation of lipid peroxidation is one of the main reasons for suppression of microsomal monooxygenases activity. A slowdown of liver microsomal oxidation might change the pharmacokinetic response of patients under drug therapy.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>23284109</pmid><doi>10.1177/0218492312444623</doi><tpages>7</tpages></addata></record>
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subjects Female
Heart Valve Diseases - surgery
Heart Valve Prosthesis Implantation
Humans
Liver - enzymology
Male
Middle Aged
Mixed Function Oxygenases - metabolism
Oxidative Stress
Postoperative Period
Prospective Studies
title Oxidative stress and liver monooxygenase function after heart valve surgery
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