Chemical Composition and Anti-Proliferative Properties of Bursera graveolens Essential Oil

Bursera graveolens is a wild tree of commercial importance native to the Neotropics, which has been widely used in folk medicine. In the present study, the chemical composition and anti-proliferative properties of the essential oil from B. graveolens were assayed. The chemical composition of the ess...

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Bibliographic Details
Published in:Natural product communications 2012-11, Vol.7 (11), p.1531-1534
Main Authors: Monzote, Lianet, Hill, Gabrielle M., Cuellar, Armando, Scull, Ramón, Setzer, William N.
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents, Phytogenic - analysis
Antiprotozoal Agents - analysis
Bursera - chemistry
Cell Proliferation - drug effects
Drug Screening Assays, Antitumor
Humans
Macrophages, Peritoneal - drug effects
MCF-7 Cells
Mice
Mice, Inbred BALB C
Oils, Volatile - chemistry
Oils, Volatile - pharmacology
Parasitic Sensitivity Tests
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Summary:Bursera graveolens is a wild tree of commercial importance native to the Neotropics, which has been widely used in folk medicine. In the present study, the chemical composition and anti-proliferative properties of the essential oil from B. graveolens were assayed. The chemical composition of the essential oil, determined by GC-MS, was complex and dominated by limonene (26.5%). Bursera oil inhibited the growth of MCF-7 breast tumor cells as well as amastigotes of L. amazonensis, with IC50 values of 48.9 ± 4.3 and 36.7 ± 4.7 μg/mL, respectively. In addition, the cytotoxicity of the oil was 103.9 ± 7.2 μg/mL against peritoneal macrophages from BALB/c mice. These results demonstrate that the essential oil from B. graveolens is a promissory antiproliferative product.
ISSN:1934-578X
1555-9475
DOI:10.1177/1934578X1200701130