Copper-Catalyzed Electrophilic Amination of Arylsilanes with Hydroxylamines

A copper-catalyzed electrophilic amination of aryl[(2-hydroxymethyl)phenyl]dimethylsilanes with O-acylated hydroxylamines has been developed to afford the corresponding anilines in good yields. The catalytic reaction proceeds very smoothly under mild conditions and tolerates a wide range of function...

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Bibliographic Details
Published in:Organic letters 2013-01, Vol.15 (1), p.172-175
Main Authors: Miki, Yuya, Hirano, Koji, Satoh, Tetsuya, Miura, Masahiro
Format: Article
Language:English
Subjects:
Amination
Aniline Compounds - chemical synthesis
Aniline Compounds - chemistry
Catalysis
Combinatorial Chemistry Techniques
Copper - chemistry
Hydroxylamines - chemistry
Molecular Structure
Silanes - chemistry
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Summary:A copper-catalyzed electrophilic amination of aryl[(2-hydroxymethyl)phenyl]dimethylsilanes with O-acylated hydroxylamines has been developed to afford the corresponding anilines in good yields. The catalytic reaction proceeds very smoothly under mild conditions and tolerates a wide range of functional groups.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol303222s