Anti-Human Coronavirus (anti-HCoV) Triterpenoids from the Leaves of Euphorbia Neriifolia

Euphorbia neriifolia L. is a spiny herb native to Southeast Asia and currently cultivated in southern Taiwan. From the ethanolic extract of E. neriifolia leaves, 23 compounds were isolated, including 22 triterpenoids and one flavonoid glycoside. The anti-human coronavirus (HCoV) activity of the sepa...

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Bibliographic Details
Published in:Natural product communications 2012-11, Vol.7 (11), p.1415-1417
Main Authors: Chang, Fang-Rong, Yen, Chiao-Ting, EI-Shazly, Mohamed, Lin, Wen-Hsun, Yen, Ming-Hong, Lin, Kuei-Hsiang, Wu, Yang-Chang
Format: Article
Language:English
Subjects:
Antiviral Agents - isolation & purification
Coronavirus
Euphorbia - chemistry
Microbial Sensitivity Tests
Molecular Structure
Plant Leaves - chemistry
Structure-Activity Relationship
Triterpenes - chemistry
Triterpenes - isolation & purification
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Summary:Euphorbia neriifolia L. is a spiny herb native to Southeast Asia and currently cultivated in southern Taiwan. From the ethanolic extract of E. neriifolia leaves, 23 compounds were isolated, including 22 triterpenoids and one flavonoid glycoside. The anti-human coronavirus (HCoV) activity of the separated triterpenoids was studied revealing the structure-activity relationship (SAR) of these isolates. 3β-Friedelanol exhibited more potent anti-viral activity than the positive control, actinomycin D, which implies the importance of the friedelane skeleton as a potential scaffold for developing new anti-HCoV-229E drugs.
ISSN:1934-578X
1555-9475
DOI:10.1177/1934578X1200701103