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A Catalytic Asymmetric Isatin-Involved Povarov Reaction: Diastereo- and Enantioselective Construction of Spiro[indolin-3,2′-quinoline] Scaffold

The first catalytic asymmetric isatin-involved Povarov reaction has been established. This method provides an unprecedented approach to access the enantioenriched spiro[indolin-3,2′-quinoline] scaffold with concomitant creation of two quaternary stereogenic centers in high yields and excellent stere...

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Bibliographic Details
Published in:Organic letters 2013-01, Vol.15 (1), p.128-131
Main Authors: Shi, Feng, Xing, Gui-Juan, Zhu, Ren-Yi, Tan, Wei, Tu, Shujiang
Format: Article
Language:English
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Summary:The first catalytic asymmetric isatin-involved Povarov reaction has been established. This method provides an unprecedented approach to access the enantioenriched spiro[indolin-3,2′-quinoline] scaffold with concomitant creation of two quaternary stereogenic centers in high yields and excellent stereoselectivities (all >99:1 dr's, up to 97% ee).
ISSN:1523-7060
1523-7052
DOI:10.1021/ol303154k