Wnt6 Is Essential for Stromal Cell Proliferation During Decidualization in Mice

Postimplantation uterine development involves extensive stromal cell proliferation and decidual transformation with polyploidization, which is essential for normal pregnancy establishment. However, it remains largely unknown how stromal proliferation versus decidual polyploidization is differentiall...

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Bibliographic Details
Published in:Biology of reproduction 2013, Vol.88 (1), p.5-5
Main Authors: QIANG WANG, JINHUA LU, KISPERT, Andreas, HAIBIN WANG, SHUANG ZHANG, SHUMIN WANG, WEIXIANG WANG, BINGYAN WANG, FENGCHAO WANG, QI CHEN, ENKUI DUAN, LEITGES, Michael
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Cell Cycle - physiology
Cell Proliferation
Embryo Implantation - physiology
Female
Fundamental and applied biological sciences. Psychology
Gene Expression Regulation, Developmental - physiology
Mice
Mice, Knockout
Polyploidy
Pregnancy
Proto-Oncogene Proteins - genetics
Proto-Oncogene Proteins - metabolism
RNA, Messenger - genetics
RNA, Messenger - metabolism
Stromal Cells - cytology
Stromal Cells - physiology
Uterus - cytology
Uterus - physiology
Vertebrates: reproduction
Wnt Proteins - genetics
Wnt Proteins - metabolism
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Summary:Postimplantation uterine development involves extensive stromal cell proliferation and decidual transformation with polyploidization, which is essential for normal pregnancy establishment. However, it remains largely unknown how stromal proliferation versus decidual polyploidization is differentially regulated during decidualization. Utilizing Wnt6-mutant mice, we show here that Wnt6 deficiency impairs stromal cell proliferation without much adverse effects on decidual polyploidization. Applying a primary stromal cell culture model, we further reveal that loss of Wnt6 prolongs the cell cycle length via downregulating cyclin B1 expression, thus attenuating stromal cell proliferation. Our study provides the first genetic evidence that Wnt6 is critical for normal stromal cell proliferation in mice, highlighting the concept that there are differential machineries governing the process of stromal cell proliferation versus decidual transformation during early pregnancy. This finding has high clinical relevance because Wnt signaling is known to be important for human implantation and endometrial function.
ISSN:0006-3363
1529-7268
DOI:10.1095/biolreprod.112.104687