CD147, MMP9 expression and clinical significance of basal-like breast cancer

Our objective is to investigate the expression of CD147 and metallo-proteinase 9 (MMP9) in patients with basal-like breast cancer (BLBC) so as to determine whether these two genes may be correlated with prognosis of BLBC. We examined the expression of the CD147 and MMP9 in BLBC by immunohistochemist...

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Published in:Medical oncology (Northwood, London, England) London, England), 2013-03, Vol.30 (1), p.366-366, Article 366
Main Authors: Liu, Ying, Xin, Tao, Jiang, Qiu-ying, Huang, Da-yong, Shen, Wei-xi, Li, Li, Lv, Yan-ju, Jin, Ying-hua, Song, Xiao-wei, Teng, Chong
Format: Article
Language:English
Subjects:
Adult
Basigin - biosynthesis
Biomarkers, Tumor - analysis
Breast cancer
Breast Neoplasms - metabolism
Breast Neoplasms - mortality
Breast Neoplasms - pathology
Disease-Free Survival
Female
Hematology
Humans
Immunohistochemistry
Internal Medicine
Kaplan-Meier Estimate
Matrix Metalloproteinase 9 - biosynthesis
Medicine
Medicine & Public Health
Neoplasm Staging
Oncology
Original Paper
Pathology
Prognosis
Proportional Hazards Models
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Summary:Our objective is to investigate the expression of CD147 and metallo-proteinase 9 (MMP9) in patients with basal-like breast cancer (BLBC) so as to determine whether these two genes may be correlated with prognosis of BLBC. We examined the expression of the CD147 and MMP9 in BLBC by immunohistochemistry. Furthermore, we analyzed the correlation between BLBC and several factors related to tumor progression, along with the prognostic value of BLBC. BLBC was significantly associated with CD147 and MMP9 expression ( P  = 0.000), and prone to lymph node metastasis and distant metastasis. Patients with BLBC showed shorter disease-free survival ( P  = 0.005) and overall survival (OS) ( P  = 0.011). In univariate analysis, CD147, MMP9, lymph node metastasis and clinical stage are independent prognostic factors affecting OS. In multivariate analysis, only clinical stage was identified as an independent prognostic factor. Patients with BLBC have a high expression of CD147 and MMP9; BLBC is correlated with a poor prognosis.
ISSN:1357-0560
1559-131X
DOI:10.1007/s12032-012-0366-x