Effect of Intraperitoneal PERIDAN™ Concentrate Adhesion Reduction Device on Clinical Findings, Infection, and Tissue Healing in an Adult Horse Jejunojejunostomy Model

Objective To evaluate the effect of PERIDAN™ Concentrate on clinical findings, infection, and tissue healing in adult horses undergoing celiotomy and jejunojejunostomy. Study Design Block randomized blinded experimental in vivo study. Animals Adult horses (n = 12). Methods Horses had jejunojejunosto...

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Bibliographic Details
Published in:Veterinary surgery 2012-07, Vol.41 (5), p.568-581
Main Authors: Morello, Samantha, Southwood, Louise L., Engiles, Julie, Slack, JoAnn, Crack, Aaron, Springate, Christopher M. K.
Format: Article
Language:English
Subjects:
Animals
Drug therapy
Gastrointestinal surgery
Horses
Jejunostomy - methods
Jejunostomy - veterinary
Jejunum - pathology
Polysaccharides - administration & dosage
Polysaccharides - therapeutic use
Surgical outcomes
Surgical Wound Infection - prevention & control
Surgical Wound Infection - veterinary
Tissue Adhesions - prevention & control
Tissue Adhesions - veterinary
Veterinary medicine
Wound Healing
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Summary:Objective To evaluate the effect of PERIDAN™ Concentrate on clinical findings, infection, and tissue healing in adult horses undergoing celiotomy and jejunojejunostomy. Study Design Block randomized blinded experimental in vivo study. Animals Adult horses (n = 12). Methods Horses had jejunojejunostomy at 2 sites and were administered 5 L of diluted PERIDAN™ Concentrate (6 horses) or Lactated Ringer's Injection (LRS) control intraperitoneally (6 horses) before body wall closure. Postoperative monitoring comprised physical examinations, serial hematology, coagulation and chemistry panels, and ultrasonographic examination. Horses were euthanatized 10 days postoperatively. Anastomoses and linea alba incisions were tested for mechanical strength; and tissue healing, inflammation, and infection were assessed by histological evaluation. Data were analyzed using a mixed model ANOVA. Level of significance was P < .05. Results No physical examination differences were observed between groups. Statistically significant differences were observed in leukocyte and neutrophil counts, prothrombin time, antithrombin III activity, intestinal bursting pressures, and histologic healing grade in the mid region of the linea alba. These differences were minimal, and of no observable clinical significance. Other blood variable and histologic differences between groups were not significant. Conclusions PERIDAN™ Concentrate was safely administered intraperitoneally to healthy horses undergoing celiotomy and anastomosis.
ISSN:0161-3499
1532-950X
DOI:10.1111/j.1532-950X.2012.00951.x