Familial leiomyomatosis cutis affecting nine family members in two successive generations including four cases of Reed's syndrome

• Published in: Indian journal of dermatology, venereology, and leprology venereology, and leprology, 2013-01, Vol.79 (1), p.83-87
• Main Authors: Mandal, Rajesh Kumar, Koley, Sankha, Banerjee, Sabyasachi, Kabiraj, Sankar Prasad, Ghosh, Sudip Kumar, Kumar, Piyush
• Format: Article
• Language: English
• Subjects: Biopsy; Case studies; Diagnosis; Drug therapy; Family medical history; Female; Fumarate Hydratase - genetics; Genetic aspects; Genetic Predisposition to Disease; Health aspects; Humans; Leiomyoma; Leiomyomatosis - genetics; Leiomyomatosis - pathology; Middle Aged; Neoplastic Syndromes, Hereditary; Nifedipine; Pedigree; Skin; Skin Neoplasms - genetics; Skin Neoplasms - pathology; Smooth muscle; Tumors; Uterine Neoplasms - genetics; Uterine Neoplasms - pathology
• ISSN: 0378-6323; 0973-3922; 1998-3611
• DOI: 10.4103/0378-6323.104674

Reed's syndrome or familial leiomyomatosis cutis et uteri is an autosomal dominant disorder, characterized by multiple cutaneous and uterine leiomyomas. We report here a case of a 53-year-old woman who presented to us with multiple painful nodules over different parts of her body. Based on the histopathological examination, imaging, and past medical records, a diagnosis of Reed's syndrome was made. Three of her sisters had similar disease. Subsequently, it was found that a total of nine members of their family in two successive generations were affected with cutaneous leiomyomas. The present case series has been reported for its interesting clinical presentations and rarity.