Tinnitus-related neural activity: Theories of generation, propagation, and centralization

• Published in: Hearing research 2013-01, Vol.295, p.161-171
• Main Authors: Noreña, Arnaud J., Farley, Brandon J.
• Format: Article
• Language: English
• Subjects: Animals; Auditory Cortex - physiopathology; Auditory Pathways - physiopathology; Auditory Perception - physiology; Brain - physiopathology; Cochlea - physiopathology; Cochlear Nerve - physiopathology; Electrophysiological Phenomena; Hearing Loss - complications; Hearing Loss - physiopathology; Humans; Models, Neurological; Neuronal Plasticity; Psychoacoustics; Sensory Deprivation - physiology; Tinnitus - etiology; Tinnitus - physiopathology
• ISSN: 0378-5955; 1878-5891
• DOI: 10.1016/j.heares.2012.09.010

The neuroscience of tinnitus represents an ideal model to explore central issues in brain functioning such as the formation of auditory percepts, in addition to opening up new treatment avenues for the condition in the long-term. The present review discusses the origin and nature of tinnitus-related neural activity. First, we review evidence for the hypothesis that tinnitus is caused by the central nervous system changes induced by sensory deprivation, even when hearing loss is not visible in the audiogram. Second, we suggest that changes in neural activity in individual central structures may not be sufficient to underlie the tinnitus percept. Instead, we propose that tinnitus may arise from functional alterations at multiple levels which promote abnormal propagation of neural activity throughout the network involved in auditory perception. In this context, functional coupling within and between central auditory structures may be especially important to consider. Investigating how sensory deprivation affects functional coupling between areas, which might be reflected in changes in temporal coherence of intrinsic ongoing activity patterns, may give critical insights into the mechanisms of tinnitus. ► Tinnitus may result from central changes produced by sensory deafferentation. ► Tinnitus may result from increased spontaneous activity and/or increased temporal coherence of cortical activity. ► Tinnitus may become centralized over time.