Pd Nanosheet-Covered Hollow Mesoporous Silica Nanoparticles as a Platform for the Chemo-Photothermal Treatment of Cancer Cells

• Published in: Small (Weinheim an der Bergstrasse, Germany) Germany), 2012-12, Vol.8 (24), p.3816-3822
• Main Authors: Fang, Weijun, Tang, Shaoheng, Liu, Pengxin, Fang, Xiaoliang, Gong, Jiawei, Zheng, Nanfeng
• Format: Article
• Language: English
• Subjects: Antineoplastic Agents - administration & dosage; Cancer; chemotherapy; Combined Modality Therapy; Doxorubicin - administration & dosage; Drug Delivery Systems; Hep G2 Cells; Hot Temperature - therapeutic use; Humans; Light therapy; mesoporous silica; nanocomposites; Nanocomposites - administration & dosage; Nanocomposites - chemistry; Nanocomposites - ultrastructure; Nanoshells - administration & dosage; Nanoshells - chemistry; Nanoshells - ultrastructure; Nanotechnology; Neoplasms - therapy; Palladium; Pd nanosheets; Phototherapy; photothermal therapy; Porous materials; Silica; Silicon Dioxide
• ISSN: 1613-6810; 1613-6829
• DOI: 10.1002/smll.201200962

A versatile system combining chemotherapy with photothermal therapy for cancer cells using Pd nanosheet‐covered hollow mesoporous silica nanoparticles is reported. While the hollow mesoporous silica core can be used to load anticancer drugs (i.e., doxorubicin) for chemotherapy, the Pd nanosheets on the surface of particles can convert NIR light into heat for photothermal therapy. More importantly, the loading of Pd nanosheets on hollow mesoporous silica nanospheres can dramatically increase the amount of cellular internalization of the Pd nanosheets: almost 11 times higher than the unloaded Pd nanosheets. The as‐prepared nanocomposites efficiently deliver both drugs and heat to cancer cells to improve the therapeutic efficiency with minimal side effects. Compared with chemotherapy or photothermal therapy alone, the combination of chemotherapy and phototherapy can significantly improve the therapeutic efficacy, exhibiting a synergistic effect. A smart Pd nanosheet‐covered hollow mesoporous silica nanocomposite is developed for the combination of chemotherapy and phototherapy to cancer cells. The novel Pd nanosheets/mesoporous silica nanocomposites are demonstrated to be more effective in cancer treatment than chemotherapy or photothermal therapy alone, and exhibit a synergistic effect.