Efficacy of red light alone and methyl-aminolaevulinate-photodynamic therapy for the treatment of mild and moderate facial acne

Photodynamic therapy (PDT) has been shown to be an effective alternative for acne. However, there is little information comparing the efficacy of red light alone and methyl aminolaevulinate (MAL)-PDT. To compare the efficacy and tolerability of red light alone and MAL-PDT in patients with mild to mo...

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Published in:Indian journal of dermatology, venereology, and leprology venereology, and leprology, 2013-01, Vol.79 (1), p.77-82
Main Authors: Pinto, Cristian, Schafer, Fabiola, Orellana, Juan Jose, Gonzalez, Sergio, Hasson, Ariel
Format: Article
Language:English
Subjects:
Acne
Acne Vulgaris - drug therapy
Adolescent
Adult
Aminolevulinic Acid - analogs & derivatives
Aminolevulinic Acid - therapeutic use
Cancer
Care and treatment
Dermatology
Face
Female
Health aspects
Humans
Light
Male
Photochemotherapy
Photochemotherapy - methods
Photodynamic therapy
Photosensitizing Agents - therapeutic use
Severity of Illness Index
Treatment Outcome
Young Adult
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Summary:Photodynamic therapy (PDT) has been shown to be an effective alternative for acne. However, there is little information comparing the efficacy of red light alone and methyl aminolaevulinate (MAL)-PDT. To compare the efficacy and tolerability of red light alone and MAL-PDT in patients with mild to moderate facial acne. Thirty six patients with mild to moderate acne were enrolled. Eighteen patients recieved MAL-PDT and 18 received red light alone in two sessions, 2 weeks apart. Acne grade and lesion counts were assessed by blinded evaluators at baseline, 2, 4 and 10 weeks. At week 2, clinical improvement from acne grade II-IV to 0-I was observed in 82.3% of MAL-PDT group and 14.2% of red light alone group. Red light alone group had a gradual clinical improvement over time with a 77% response at week 10. In contrast, MAL-PDT group had a rapid clinical improvement with total response at week 10. Both treatments were significantly effective for improving acne lesions. However, MAL-PDT group had a greater response (P < 0.001). Histologically, decreased amounts of sebocytes and lipids along with atrophic sebaceous glands were observed after MAL-PDT. MAL-PDT has a quicker onset of action with a higher response than red light alone. MAL-PDT may induce a reduction in the size of the sebaceous glands and then long-term acne remission.
ISSN:0378-6323
0973-3922
1998-3611
DOI:10.4103/0378-6323.104673