Flavopiridol inhibits interferon-γ-induced nitric oxide production in mouse vascular endothelial cells

Highlights ► Flavopiridol inhibits interferon-gamma induced nitric oxide production. ► Flavopiridol inhibits the activation of STAT1 in interferong-gamma signaling. ► Flavopiridol regulates the function of vascular endothelial cells. ► Flavopiridol has an immunomodulatory action on inflammation....

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Bibliographic Details
Published in:Immunology letters 2012-12, Vol.148 (2), p.91-96
Main Authors: Terashima, Tsuguaki, Haque, Abedul, Kajita, Yuka, Takeuchi, Akinori, Nakagawa, Takashi, Yokochi, Takashi
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animals
Cell Line
Cell surface
Cell Survival
Cyclin-Dependent Kinases - antagonists & inhibitors
Endothelial Cells - metabolism
Enzyme Activation - drug effects
Flavonoids - pharmacology
Flavopiridol (FP)
Immunomodulation
Inducible NO synthase (iNOS)
Interferon Regulatory Factor-1 - metabolism
Interferon-gamma (IFN-γ)
Interferon-gamma - metabolism
Mice
Nitric oxide (NO)
Nitric Oxide - biosynthesis
Nitric Oxide - metabolism
Piperidines - pharmacology
Protein Kinase Inhibitors - pharmacology
Signal transducer and activator of transcription 1 (STAT1)
Signal Transduction - drug effects
STAT1 Transcription Factor - metabolism
Vascular endothelial cells
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Summary:Highlights ► Flavopiridol inhibits interferon-gamma induced nitric oxide production. ► Flavopiridol inhibits the activation of STAT1 in interferong-gamma signaling. ► Flavopiridol regulates the function of vascular endothelial cells. ► Flavopiridol has an immunomodulatory action on inflammation.
ISSN:0165-2478
1879-0542
DOI:10.1016/j.imlet.2012.10.004