Antihyperglycemic and antihyperlipidemic action of cinnamaldehyde in C57blks/j Db/db mice

• Published in: Journal of traditional Chinese medicine 2012-09, Vol.32 (3), p.446-452
• Main Authors: Li, Juane, Liu, Tonghua, Wang, Lei, Guo, Xiangyu, Xu, Tunhai, Wu, Lili, Qin, Lingling, Sun, Wen
• Format: Article
• Language: English
• Subjects: Acrolein - administration & dosage; Acrolein - analogs & derivatives; Adiponectin - metabolism; Animals; Cinnamomum zeylanicum - chemistry; Diabetes Mellitus, Type 2 - drug therapy; Diabetes Mellitus, Type 2 - genetics; Diabetes Mellitus, Type 2 - metabolism; Fatty Acids, Nonesterified - metabolism; Glucose Transporter Type 4 - genetics; Glucose Transporter Type 4 - metabolism; Humans; Hypoglycemic Agents - administration & dosage; Hypolipidemic Agents - administration & dosage; Insulin - metabolism; Male; Mice; mRNA含量; Plant Extracts - administration & dosage; Tumor Necrosis Factor-alpha - genetics; Tumor Necrosis Factor-alpha - metabolism; 低密度脂蛋白胆固醇; 小鼠; 肉桂醛; 降血糖; 降血脂; 高密度脂蛋白胆固醇
• ISSN: 0255-2922
• DOI: 10.1016/S0254-6272(13)60053-9

OBJECTIVE：To investigate the effects of cinnamaldehyde（CA）,an active and major compound in cinnamon,on glucose metabolism and insulin resistance in C57BLKS/J db/db mice.METHODS：Sixteen male C57BLKS db/db mice were randomly divided into control and CA treatment groups.CA was given（20 mg.kg-1.day-1,p.o.） for 4 weeks.Pure water was given to control and db/＋ mice.Subsequently,the levels of fasting blood glucose（FBG）,fasting serum insulin,triglyeride,cholesterol,low-density lipoprotein-cholesterol（LDL-C）,high-density lipoprotein-cholesterol（HDL-C）,and free fatty acids（FFA）,as well as the mRNA content of adiponectin and tumor necrosis factor（TNF）-α in adipose tissue,glucose transporter type 4（GLUT-4） in skeletal muscle,and protein expressions of Akt,phospho-Akt（Thr308）,AMPKα,phospho-AMPKα（Thr172） in skeletal muscle were measured.RESULTS：1） CA decreased serum levels of FBG and insulin as well as body weight in db/db mice;2） CA increased serum HDL-C levels;3） CA significantly decreased the mRNA expression of TNF-α in adipose tissue and upregulated mRNA expression of GLUT-4 in skeletal muscle;4） protein expression of p-Akt was increased in CA-treated mice,but Akt,AMPKα and p-AMPKα showed no change.CONCLUSION：CA has antihyperglycemic and antihyperlipidemic actions in db/db mice and could be useful in the treatment of type-2 diabetes.