ANCA-associated vasculitis with dual ANCA positivity in coexistence with mixed connective tissue disease

We here report a rare case of dual antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) in a 38-year-old Japanese woman previously diagnosed with mixed connective tissue disease. The patient was found to be positive for myeloperoxidase- and proteinase 3-ANCA, and was diagnosed with...

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Bibliographic Details
Published in:Modern rheumatology 2013, Vol.23 (1), p.156-161
Main Authors: Murakami, Masanori, Shimane, Kenichi, Takahashi, Hiroshi, Tomiyama, Junji, Nagashima, Masakazu
Format: Article
Language:English
Subjects:
Case Report
Medicine
Medicine & Public Health
Orthopedics
Rheumatology
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Summary:We here report a rare case of dual antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) in a 38-year-old Japanese woman previously diagnosed with mixed connective tissue disease. The patient was found to be positive for myeloperoxidase- and proteinase 3-ANCA, and was diagnosed with AAV following admission to hospital with fervescence, polyarthralgia, purpura, and asymmetric numbness of the extremities. Examination of her genetic background revealed that she carried HLA-DR9, which confers risk of both diseases in Japanese populations.
ISSN:1439-7595
1439-7609
DOI:10.1007/s10165-012-0619-8