Influence of semi-quantitative oestrogen receptor expression on adjuvant endocrine therapy efficacy in ductal and lobular breast cancer – A TEAM study analysis

Abstract Background Multiple studies suggest better efficacy of chemotherapy in invasive ductal breast carcinomas (IDC) than invasive lobular breast carcinomas (ILC). However, data on efficacy of adjuvant endocrine therapy regimens and histological subtypes are sparse. This study assessed endocrine...

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Published in:European journal of cancer (1990) 2013-01, Vol.49 (2), p.297-304
Main Authors: van de Water, Willemien, Fontein, Duveken B.Y, van Nes, Johanna G.H, Bartlett, John M.S, Hille, Elysée T.M, Putter, Hein, Robson, Tammy, Liefers, Gerrit-Jan, Roumen, Rudi M.H, Seynaeve, Caroline, Dirix, Luc Y, Paridaens, Robert, Kranenbarg, Elma Meershoek-Klein, Nortier, Johan W.R, van de Velde, Cornelis J.H
Format: Article
Language:English
Subjects:
Aged
Androstadienes - administration & dosage
Androstadienes - therapeutic use
Antineoplastic Agents, Hormonal - administration & dosage
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Biological and medical sciences
Breast cancer
Breast Neoplasms - drug therapy
Breast Neoplasms - metabolism
Breast Neoplasms - pathology
Carcinoma, Ductal, Breast - drug therapy
Carcinoma, Ductal, Breast - metabolism
Carcinoma, Ductal, Breast - pathology
Carcinoma, Lobular - drug therapy
Carcinoma, Lobular - metabolism
Carcinoma, Lobular - pathology
Chemotherapy, Adjuvant
Endocrine therapy
Female
Hematology, Oncology and Palliative Medicine
Humans
Lobular carcinoma
Medical sciences
Oestrogen receptors
Pharmacology. Drug treatments
Postmenopause
Receptors, Estrogen - biosynthesis
Tamoxifen - administration & dosage
Tumors
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Summary:Abstract Background Multiple studies suggest better efficacy of chemotherapy in invasive ductal breast carcinomas (IDC) than invasive lobular breast carcinomas (ILC). However, data on efficacy of adjuvant endocrine therapy regimens and histological subtypes are sparse. This study assessed endocrine therapy efficacy in IDC and ILC. The influence of semi-quantitative oestrogen receptor (ER) expression by Allred score was also investigated. Methods Dutch and Belgian patients enrolled in the Tamoxifen Exemestane Adjuvant Multinational (TEAM) trial were randomized to exemestane (25 mg daily) alone or following tamoxifen (20 mg daily) for 5 years. Inclusion was restricted to IDC and ILC patients. Histological subtype was assessed locally; ER expression was centrally reviewed according to Allred score (ER-poor (
ISSN:0959-8049
1879-0852
DOI:10.1016/j.ejca.2012.07.026