Comparison of transdermal electromotive administration of verapamil and dexamethasone versus intra‐lesional injection for Peyronie's disease

• Published in: Andrology (Oxford) 2013-01, Vol.1 (1), p.129-132
• Main Authors: Mehrsai, A. R., Namdari, F., Salavati, A., Dehghani, S., Allameh, F., Pourmand, G.
• Format: Article
• Language: English
• Subjects: Administration, Cutaneous; Analysis of Variance; Biological and medical sciences; Calcium Channel Blockers - administration & dosage; dexamethasone; Dexamethasone - administration & dosage; Drug Therapy, Combination; Glucocorticoids - administration & dosage; Gynecology. Andrology. Obstetrics; Humans; Injections, Intralesional; intralesional injection; Iontophoresis; Iran; Male; Male genital diseases; Medical sciences; Non tumoral diseases; Penile Induration - diagnosis; Penile Induration - drug therapy; Peyronie's disease; Prospective Studies; Time Factors; transdermal electromotive administration; Treatment Outcome; verapamil; Verapamil - administration & dosage
• ISSN: 2047-2919; 2047-2927
• DOI: 10.1111/j.2047-2927.2012.00018.x

Summary To compare the efficacy of transdermal electromotive administration and intra‐lesional injection of verapamil plus dexamethasone for the treatment of Peyronie's disease. Patients with Peyronie's disease of less than 2‐year duration were randomized into two groups of transdermal electromotive administration and intra‐lesional injection of verapamil plus dexamethasone. During the 6‐week therapy period, a single weekly dose of 10 mg verapamil and 4 mg dexamethasone solution was administered to 30 patients in each group either by transdermal electromotive method or via the conventional injection method by a syringe connected to a 25 G needle. Evaluations of plaque length, width, and volume, penile curvature, erectile dysfunction and penile deviations were carried out before and after 1 and 3 months of the interventions. Erectile pain was reduced in the electromotive group from a mean of 5.1–1.0 in scale of 10 and from 5.4 to 3.6 in the injection group (p = 0.006). Regarding plaque length, plaque width, penile curvature plaque volume and erectile dysfunction, the electromotive administration group showed better results which, however, were not statistically significant. (p > 0.05). Transdermal electromotive drug administration yielded comparable results as against current conventional intra‐lesional injection technique and fared better in controlling erectile pain.