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Comparison of transdermal electromotive administration of verapamil and dexamethasone versus intra‐lesional injection for Peyronie's disease

Summary To compare the efficacy of transdermal electromotive administration and intra‐lesional injection of verapamil plus dexamethasone for the treatment of Peyronie's disease. Patients with Peyronie's disease of less than 2‐year duration were randomized into two groups of transdermal ele...

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Published in:Andrology (Oxford) 2013-01, Vol.1 (1), p.129-132
Main Authors: Mehrsai, A. R., Namdari, F., Salavati, A., Dehghani, S., Allameh, F., Pourmand, G.
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description Summary To compare the efficacy of transdermal electromotive administration and intra‐lesional injection of verapamil plus dexamethasone for the treatment of Peyronie's disease. Patients with Peyronie's disease of less than 2‐year duration were randomized into two groups of transdermal electromotive administration and intra‐lesional injection of verapamil plus dexamethasone. During the 6‐week therapy period, a single weekly dose of 10 mg verapamil and 4 mg dexamethasone solution was administered to 30 patients in each group either by transdermal electromotive method or via the conventional injection method by a syringe connected to a 25 G needle. Evaluations of plaque length, width, and volume, penile curvature, erectile dysfunction and penile deviations were carried out before and after 1 and 3 months of the interventions. Erectile pain was reduced in the electromotive group from a mean of 5.1–1.0 in scale of 10 and from 5.4 to 3.6 in the injection group (p = 0.006). Regarding plaque length, plaque width, penile curvature plaque volume and erectile dysfunction, the electromotive administration group showed better results which, however, were not statistically significant. (p > 0.05). Transdermal electromotive drug administration yielded comparable results as against current conventional intra‐lesional injection technique and fared better in controlling erectile pain.
doi_str_mv 10.1111/j.2047-2927.2012.00018.x
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subjects Administration, Cutaneous
Analysis of Variance
Biological and medical sciences
Calcium Channel Blockers - administration & dosage
dexamethasone
Dexamethasone - administration & dosage
Drug Therapy, Combination
Glucocorticoids - administration & dosage
Gynecology. Andrology. Obstetrics
Humans
Injections, Intralesional
intralesional injection
Iontophoresis
Iran
Male
Male genital diseases
Medical sciences
Non tumoral diseases
Penile Induration - diagnosis
Penile Induration - drug therapy
Peyronie's disease
Prospective Studies
Time Factors
transdermal electromotive administration
Treatment Outcome
verapamil
Verapamil - administration & dosage
title Comparison of transdermal electromotive administration of verapamil and dexamethasone versus intra‐lesional injection for Peyronie's disease
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