The relationship between anogenital distance and age

Summary In humans, recent studies have correlated anogenital distance (AGD) in adult men to intrinsic testicular function. Although rodent studies suggest that AGD is determined in utero and remains constant in adult life, it is not certain if AGD remains constant across a man's adult life. We...

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Bibliographic Details
Published in:Andrology (Oxford) 2013-01, Vol.1 (1), p.90-93
Main Authors: Eisenberg, M. L., Hsieh, T.‐C., Lipshultz, L. I.
Format: Article
Language:English
Subjects:
Adult
Age Factors
Aged
Anal Canal - anatomy & histology
Anal Canal - growth & development
Analysis of Variance
azoospermia
Biological and medical sciences
Birth control
Cross-Sectional Studies
genitalia
Gynecology. Andrology. Obstetrics
Humans
Linear Models
Male
Medical sciences
Middle Aged
Penis - anatomy & histology
perineum
Scrotum - anatomy & histology
Scrotum - growth & development
Sterility. Assisted procreation
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Summary:Summary In humans, recent studies have correlated anogenital distance (AGD) in adult men to intrinsic testicular function. Although rodent studies suggest that AGD is determined in utero and remains constant in adult life, it is not certain if AGD remains constant across a man's adult life. We sought to determine if adult male AGD varies based on age. A cross‐sectional study of men being evaluated at a men's health clinic. Anogenital distance (the distance from the posterior aspect of the scrotum to the anal verge) and penile length (PL) were measured using digital callipers. anova and linear regression were used to determine correlations between AGD, fatherhood status and age. In all, 473 men were included in the analysis with a mean age of 43 ± 13 years. The mean AGD for the group was 39 ± 13 mm. Anogenital distance did not vary between age categories for the entire group, for fathers, and for childless men. Moreover, penile length also remained constant across age categories. On adjusted analyses stratified by fatherhood status, there was no relationship between AGDp and age. The current cross‐sectional study demonstrates that anogenital distance, defined as the distance from the posterior scrotum to the anal verge, is similar for men of different ages. As such, AGD may provide a measure for genital development and function throughout adult life. However, confirmation with longitudinal studies is needed.
ISSN:2047-2919
2047-2927
DOI:10.1111/j.2047-2927.2012.00019.x