The role of vascular endothelial growth factor-D in diagnosis of lymphangioleiomyomatosis (LAM)

Summary Background Definite diagnosis of lymphangioleiomyomatosis (LAM) depends on either transbronchial lung biopsy or video-assisted thoracic surgery, unless there is a history of chylothorax, kidney angiomyolipoma (AML), or tuberous sclerosis complex (TSC). Vascular endothelial growth factor-D (V...

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Published in:Respiratory medicine 2013-02, Vol.107 (2), p.263-268
Main Authors: Xu, Kai-Feng, Zhang, Peng, Tian, Xinlun, Ma, Aiping, Li, Xue, Zhou, Jiong, Zeng, Ni, Gui, Yao-Song, Guo, Zijian, Feng, Ruie, Zhang, Weihong, Sun, Wei, Cai, Baiqiang
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Biomarkers - blood
Case-Control Studies
Chylous Ascites - blood
Chylous Ascites - etiology
Diagnosis
Enzyme-Linked Immunosorbent Assay - methods
Female
Humans
Lymphangioleio-myomatosis
Lymphangioleiomyomatosis - complications
Lymphangioleiomyomatosis - diagnosis
Lymphangioleiomyomatosis - diagnostic imaging
Medical sciences
Middle Aged
Pneumology
Pulmonary/Respiratory
Severity of Illness Index
Tomography, X-Ray Computed
Vascular Endothelial Growth Factor D - blood
Vascular endothelial growth factor-D (VEGF-D)
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Summary:Summary Background Definite diagnosis of lymphangioleiomyomatosis (LAM) depends on either transbronchial lung biopsy or video-assisted thoracic surgery, unless there is a history of chylothorax, kidney angiomyolipoma (AML), or tuberous sclerosis complex (TSC). Vascular endothelial growth factor-D (VEGF-D) was recently considered as a novel diagnostic marker for LAM. Herein, we evaluated diagnostic value of serum VEGF-D in LAM patients. Methods Serum samples were obtained from 78 cases of LAM (50 definite and 28 probable LAM based on European Respiratory Society guidelines), and 40 healthy female volunteers. VEGF-D was measured using enzyme-linked immunosorbant assay according to product instruction (R&D). Results Serum VEGF-D was significantly increased in definite LAM group, compared with that of health control (median: 3841.9 pg/mL vs 405.5 pg/mL respectively, p  
ISSN:0954-6111
1532-3064
DOI:10.1016/j.rmed.2012.10.006