The rs9939609 Gene Variant in FTO Modified the Metabolic Response of Weight Loss After a 3-Month Intervention With a Hypocaloric Diet

• Published in: Journal of investigative medicine 2013-01, Vol.61 (1), p.22-26
• Main Authors: de Luis, Daniel Antonio, Aller, Rocío, Conde, Rosa, Izaola, Olatz, Sagrado, Manuel Gonzalez, Castrodeza Sanz, Javier
• Format: Article
• Language: English
• Subjects: Adult; Aged; Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Caloric Restriction - methods; Diet, Fat-Restricted - methods; Diet, Reducing - methods; Female; Genetic Variation - genetics; Humans; Male; Middle Aged; Obesity - diet therapy; Obesity - genetics; Prospective Studies; Proteins - genetics; Time Factors; Weight Loss - genetics
• ISSN: 1081-5589; 1708-8267
• DOI: 10.2310/JIM.0b013e318276161d

BackgroundCommon polymorphisms in the fat mass and obesity associated gene (FTO) have been linked to obesity in some populations. Nevertheless, the role of FTO variants on body weight response after dietary intervention remains equivocal.ObjectiveWe decided to analyze the effects of the rs9939609 FTO gene polymorphism on body weight changes and metabolic parameters after 3 months of a hypocaloric diet.DesignBefore and after 3 months on a low-fat hypocaloric diet, a white population of 106 subjects with obesity was analyzed.ResultsOf the study subjects, 35 (33%) had the genotype TT and 71 (67%) had the next genotypes; TA (46 study subjects, 43.4%) or AA (25 study subjects, 23.6%). After dietary treatment and in TT group, weight, waist circumference, total cholesterol, LDL-cholesterol, insulin, and homeostasis model assessment decreases were less than subjects carrying the A allele [−3.1 (3.6) vs −2.4 (4.1) kg: P < 0.05], waist circumference [−5.4 (6.4) vs −2.6 (4.8) cm; P < 0.05], total cholesterol [−12.3 (35.3) vs −6.4 (4.7) mg/dL; P < 0.05], LDL-cholesterol [−22.3 (30.5) vs −10.7 (30.5) mg/dL; P < 0.05], insulin [−1.89 (5.5) vs +0.94 (8.2) mUI/L; P < 0.05], and homeostasis model assessment [−0.46 (1.11) vs −0.01 (2.4); P < 0.05].ConclusionsOur study confirmed a higher weight loss in A carriers of FTO rs9939609 polymorphism than in TT genotype study subjects.