Cardiac Conduction Block at Multiple Levels Caused by Arsenic Trioxide Therapy

Abstract We present a rare case of a woman aged 62 years with refractory acute promyelocytic leukemia treated with arsenic trioxide leading to progressive, multilevel cardiac conduction block. After chelation treatment with dimercaprol, there was normalization of conduction.

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Bibliographic Details
Published in:Canadian journal of cardiology 2013, Vol.29 (1), p.130.e5-130.e6
Main Authors: Kathirgamanathan, Kala, MD, Angaran, Paul, MD, Lazo-Langner, Alejandro, MD, Gula, Lorne J., MD, MSc
Format: Article
Language:English
Subjects:
Antineoplastic Agents - adverse effects
Antineoplastic Agents - therapeutic use
Arsenicals - adverse effects
Arsenicals - therapeutic use
Cardiovascular
Chelating Agents - therapeutic use
Dimercaprol - therapeutic use
Electrocardiography - drug effects
Female
Follow-Up Studies
Growth Inhibitors
Heart Block - chemically induced
Heart Block - drug therapy
Heart Block - physiopathology
Heart Conduction System - drug effects
Heart Conduction System - physiopathology
Humans
Leukemia, Promyelocytic, Acute - drug therapy
Middle Aged
Oxides - adverse effects
Oxides - therapeutic use
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Description
Summary:Abstract We present a rare case of a woman aged 62 years with refractory acute promyelocytic leukemia treated with arsenic trioxide leading to progressive, multilevel cardiac conduction block. After chelation treatment with dimercaprol, there was normalization of conduction.
ISSN:0828-282X
1916-7075
DOI:10.1016/j.cjca.2012.04.004