Production of cytokines by mononuclear cells of hypertrophic adenoids in children with otitis media with effusion

Hypertrophic adenoids with otitis media with effusion is a common infectious disease and present a serious otological problem in children. Cytokines, potent inflammatory mediators, play important role in the initiation of immunological response in otitis media. Adenoids excised due to hypertrophy wi...

Full description

Saved in:
Bibliographic Details
Published in:Folia histochemica et cytobiologica 2012, Vol.50 (4), p.586-589
Main Authors: Zelazowska-Rutkowska, Beata, Ilendo, Elzbieta, Skotnicka, Bozena, Wysocka, Jolanta, Kasprzycka, Edwina
Format: Article
Language:English
Subjects:
Adenoids - pathology
Adolescent
Child
Child, Preschool
Cytokines - biosynthesis
Humans
Hypertrophy
Leukocytes, Mononuclear - metabolism
Otitis Media with Effusion - complications
Otitis Media with Effusion - pathology
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Hypertrophic adenoids with otitis media with effusion is a common infectious disease and present a serious otological problem in children. Cytokines, potent inflammatory mediators, play important role in the initiation of immunological response in otitis media. Adenoids excised due to hypertrophy with or without chronic otitis media with effusion were used to isolate mononuclear cells. Secretion of cytokines by non-stimulated and PHA-stimulated cells was determined by specific ELISAs. We found a significant increase in the production of IL-5 and TNF-α secreted by adenoidal cells of children with otitis media with effusion compared to group with hypertrophic adenoids. No differences were found in the secretion of IL-8, IL-6, and IL-10 between these two groups of patients. Our results suggest a difference between the immunological responses in the course of hypertrophic adenoids with otitis media as compared to hypertrophic adenoids.
ISSN:1897-5631
DOI:10.5603/20326