Evaluation of presumptive biomarkers of oxidative stress, immune response and apoptosis in primary open-angle glaucoma

Highlights ► Oxidative stress, immune response and apoptosis in POAG initiation and progression. ► Putative glaucoma biomarkers are MDA, TAS, 8-OH-dG, ILs-1α/6, Cas-2/3/14 and PARP-1. ► Certain antibodies and cytokines vary in relation to POAG in aqueous humor and serum. ► Apoptosis biomarkers from...

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Bibliographic Details
Published in:Current opinion in pharmacology 2013-02, Vol.13 (1), p.98-107
Main Authors: Pinazo-Durán, Maria D, Zanón-Moreno, Vicente, García-Medina, Jose J, Gallego-Pinazo, Roberto
Format: Article
Language:English
Subjects:
Animals
Apoptosis
biomarkers
Biomarkers - metabolism
Blindness
Glaucoma
Glaucoma, Open-Angle - immunology
Glaucoma, Open-Angle - metabolism
Humans
Immune response
Inflammation
Inflammation - immunology
Inflammation - metabolism
Internal Medicine
Medical Education
Oxidative Stress
Reactive oxygen species
Reviews
Signal transduction
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Summary:Highlights ► Oxidative stress, immune response and apoptosis in POAG initiation and progression. ► Putative glaucoma biomarkers are MDA, TAS, 8-OH-dG, ILs-1α/6, Cas-2/3/14 and PARP-1. ► Certain antibodies and cytokines vary in relation to POAG in aqueous humor and serum. ► Apoptosis biomarkers from blood and virtually every ocular sample might apply to POAG. ► Advances in biotechnology offer remarkable opportunities for glaucoma research.
ISSN:1471-4892
1471-4973
DOI:10.1016/j.coph.2012.10.007