Poly I:C-induced activation of the immune response is accompanied by depression and anxiety-like behaviours, kynurenine pathway activation and reduced BDNF expression

Highlights ► Depressive and anxiety-like behaviours elicited by poly I:C are associated with a reduction in BDNF signalling, and activation of the kynurenine pathway, but not a reduction in serotonin.

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Bibliographic Details
Published in:Brain, behavior, and immunity behavior, and immunity, 2013-02, Vol.28, p.170-181
Main Authors: Gibney, Sinead M, McGuinness, Barry, Prendergast, Christine, Harkin, Andrew, Connor, Thomas J
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animals
Anxiety - chemically induced
Anxiety - immunology
BDNF
Brain-Derived Neurotrophic Factor - antagonists & inhibitors
Brain-Derived Neurotrophic Factor - physiology
CD11b Antigen - physiology
Cytokine
Depression
Depression - chemically induced
Depression - immunology
Frontal Lobe - metabolism
Hippocampus - metabolism
IDO
IL-1
IL-6
Illness Behavior - physiology
Inflammation
Interleukin-1beta - physiology
Interleukin-6 - physiology
Kynurenine
Kynurenine - physiology
Male
Poly I-C - pharmacology
Poly I:C
Psychiatry
Rats
Rats, Sprague-Dawley
Serotonin
Signal Transduction - drug effects
Signal Transduction - physiology
TNF-α
Tumor Necrosis Factor-alpha - physiology
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Description
Summary:Highlights ► Depressive and anxiety-like behaviours elicited by poly I:C are associated with a reduction in BDNF signalling, and activation of the kynurenine pathway, but not a reduction in serotonin.
ISSN:0889-1591
1090-2139
DOI:10.1016/j.bbi.2012.11.010