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Poly I:C-induced activation of the immune response is accompanied by depression and anxiety-like behaviours, kynurenine pathway activation and reduced BDNF expression
Highlights ► Depressive and anxiety-like behaviours elicited by poly I:C are associated with a reduction in BDNF signalling, and activation of the kynurenine pathway, but not a reduction in serotonin.
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| Published in: | Brain, behavior, and immunity behavior, and immunity, 2013-02, Vol.28, p.170-181 |
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| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c441t-ff4cd23e1f27ee99c2551a3a0b782082e4140db8d4ee26e14715dfd2c063a5503 |
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| cites | cdi_FETCH-LOGICAL-c441t-ff4cd23e1f27ee99c2551a3a0b782082e4140db8d4ee26e14715dfd2c063a5503 |
| container_end_page | 181 |
| container_issue | |
| container_start_page | 170 |
| container_title | Brain, behavior, and immunity |
| container_volume | 28 |
| creator | Gibney, Sinead M McGuinness, Barry Prendergast, Christine Harkin, Andrew Connor, Thomas J |
| description | Highlights ► Depressive and anxiety-like behaviours elicited by poly I:C are associated with a reduction in BDNF signalling, and activation of the kynurenine pathway, but not a reduction in serotonin. |
| doi_str_mv | 10.1016/j.bbi.2012.11.010 |
| format | article |
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| fulltext | fulltext |
| identifier | ISSN: 0889-1591 |
| ispartof | Brain, behavior, and immunity, 2013-02, Vol.28, p.170-181 |
| issn | 0889-1591 1090-2139 |
| language | eng |
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| source | Elsevier |
| subjects | Allergy and Immunology Animals Anxiety - chemically induced Anxiety - immunology BDNF Brain-Derived Neurotrophic Factor - antagonists & inhibitors Brain-Derived Neurotrophic Factor - physiology CD11b Antigen - physiology Cytokine Depression Depression - chemically induced Depression - immunology Frontal Lobe - metabolism Hippocampus - metabolism IDO IL-1 IL-6 Illness Behavior - physiology Inflammation Interleukin-1beta - physiology Interleukin-6 - physiology Kynurenine Kynurenine - physiology Male Poly I-C - pharmacology Poly I:C Psychiatry Rats Rats, Sprague-Dawley Serotonin Signal Transduction - drug effects Signal Transduction - physiology TNF-α Tumor Necrosis Factor-alpha - physiology |
| title | Poly I:C-induced activation of the immune response is accompanied by depression and anxiety-like behaviours, kynurenine pathway activation and reduced BDNF expression |
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