The 2-global flash mfERG in glaucoma: attempting to increase sensitivity by reducing the focal flash luminance and changing filter settings

Purpose To test a new 2-flash multifocal electroretinogram (mfERG) paradigm in glaucoma using a reduced light intensity of the m-frame flash as opposed to the global flash, as it has been suggested that this may increase the responses induced by the global flash, which has been the part of the mfERG...

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Bibliographic Details
Published in:Documenta ophthalmologica 2013-02, Vol.126 (1), p.57-67
Main Authors: Kramer, S. A., Ledolter, A. A., Todorova, M. G., Schötzau, A., Orgül, S., Palmowski-Wolfe, A. M.
Format: Article
Language:English
Subjects:
Adult
Aged
Contrast Sensitivity - physiology
Electroretinography - methods
Female
Filtration
Glaucoma
Glaucoma - diagnosis
Glaucoma - physiopathology
Humans
Light
Male
Medicine
Medicine & Public Health
Middle Aged
Ophthalmology
Original Research Article
Photic Stimulation - methods
Retina - physiopathology
ROC Curve
Visual Fields - physiology
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Summary:Purpose To test a new 2-flash multifocal electroretinogram (mfERG) paradigm in glaucoma using a reduced light intensity of the m-frame flash as opposed to the global flash, as it has been suggested that this may increase the responses induced by the global flash, which has been the part of the mfERG response where most changes have been noted in glaucoma. Methods A mfERG was recorded from one eye of 22 primary open angle glaucoma (POAG) patients [16 normal tension glaucoma (NTG), 6 high tension glaucoma (HTG)] and 20 control subjects. A binary m-sequence (2^13-1, L max 100 cd/m 2 , L min
ISSN:0012-4486
1573-2622
DOI:10.1007/s10633-012-9360-z