Treatment of Arterial Remodeling in Essential Hypertension

Essential hypertension is associated with large and small vascular remodeling that impacts cardiovascular prognosis. Longitudinal follow-up of hypertensive patients has shown that large arterial stiffness decreases partly independently of blood pressure reduction, suggesting specific pharmacological...

Full description

Saved in:
Bibliographic Details
Published in:Current hypertension reports 2013-02, Vol.15 (1), p.3-9
Main Authors: Briet, Marie, Schiffrin, Ernesto L.
Format: Article
Language:English
Subjects:
Angiotensin Receptor Antagonists - pharmacology
Angiotensin Receptor Antagonists - therapeutic use
Angiotensin-Converting Enzyme Inhibitors - pharmacology
Angiotensin-Converting Enzyme Inhibitors - therapeutic use
Antihypertensive Agents - pharmacology
Antihypertensive Agents - therapeutic use
Blood Pressure - drug effects
Cardiology
Elasticity - drug effects
Family Medicine
General Practice
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology
Hypertension
Hypertension - drug therapy
Hypertension - physiopathology
Hypertension and the Kidney (RM Carey and A Mimran
Internal Medicine
Kidney - blood supply
Kidney - physiopathology
Life Style
Medicine
Medicine & Public Health
Metabolic Diseases
Nephrology
Primary Care Medicine
Section Editors
Vascular Stiffness - drug effects
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Essential hypertension is associated with large and small vascular remodeling that impacts cardiovascular prognosis. Longitudinal follow-up of hypertensive patients has shown that large arterial stiffness decreases partly independently of blood pressure reduction, suggesting specific pharmacological effects of antihypertensive therapy. Inhibitors of the renin-angiotensin-aldosterone system are among the agents that have been shown to affect vascular remodeling to a greater degree. Lifestyle modifications, including exercise and weight reduction, also improve large and small vascular remodeling. New antihypertensive drugs, including neprilysin inhibitors associated with an angiotensin receptor blocker, aldosterone synthase inhibitors and new devices such as renal denervation and baroreceptor stimulation, may exert beneficial effects on vascular remodeling and are currently under evaluation.
ISSN:1522-6417
1534-3111
DOI:10.1007/s11906-012-0325-0