Epstein-Barr virus DNA associated with gastric adenocarcinoma and adjacent non-cancerous mucosa in patients from Manaus, Brazil

Gastric cancer is one of most frequent causes of death in Brazil. The city of Manaus has one of the highest incidences of this disease in Brazil. The Epstein-Barr virus (EBV) is a ubiquitous herpesvirus that is classified as a group 1 carcinogen by the International Agency for Research on Cancer. We...

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Bibliographic Details
Published in:Genetics and molecular research 2012-01, Vol.11 (4), p.4442-4446
Main Authors: de Aquino, P F, Carvalho, P C, da Gama Fischer, J S, de Souza, A Q L, Viana, J S, Chalub, S R S, de Souza, A D L, Carvalho, M G C
Format: Article
Language:English
Subjects:
Adenocarcinoma - virology
Adult
Aged
Brazil
Case-Control Studies
DNA, Viral - genetics
Epstein-Barr Virus Infections - complications
Epstein-Barr Virus Infections - virology
Female
Gastric Mucosa - pathology
Gastric Mucosa - virology
Herpesvirus 4, Human - genetics
Humans
Male
Middle Aged
Risk Factors
Stomach Neoplasms - virology
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Summary:Gastric cancer is one of most frequent causes of death in Brazil. The city of Manaus has one of the highest incidences of this disease in Brazil. The Epstein-Barr virus (EBV) is a ubiquitous herpesvirus that is classified as a group 1 carcinogen by the International Agency for Research on Cancer. We obtained biopsies from 6 control subjects and 10 patients with gastric carcinomas living in Manaus. In the patients, the samples were taken from tumors and from adjacent non-cancerous mucosa. These samples were screened for EBV DNA by PCR to amplify the 288-bp fragments from the Bam M region. The EBV DNA was detected in 8 of the 10 tumor cases and in none of the 6 control subjects. In the positively identified samples, EBV DNA was detected in five corresponding resection margins. Previous research indicated only a weak association between EBV and gastric cancer. We suggest that EBV should be considered as a risk factor for gastric adenocarcinomas in Manaus.
ISSN:1676-5680
1676-5680
DOI:10.4238/2012.October.15.3