Renal Dysfunction is Common Among Adults After Palliation for Previous Tetralogy of Fallot

Long-term survival after tetralogy of Fallot (TOF) repair is excellent. However, little is published regarding late noncardiac complications. This study aimed to determine the prevalence and risk factors for renal dysfunction among adults after TOF repair. For this study, 56 adult patients with comp...

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Bibliographic Details
Published in:Pediatric cardiology 2013, Vol.34 (1), p.165-169
Main Authors: Buelow, Matthew W., Dall, Aaron, Bartz, Peter J., Tweddell, James S., Sowinski, Jane, Rudd, Nancy, Katzmark, Lindsey, Earing, Michael G.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Adults
Aged
Cardiac Surgery
Cardiology
Chronic kidney failure
Complications and side effects
Diuretics
Female
Follow-Up Studies
Glomerular Filtration Rate
Humans
Hypertension
Kidney - physiopathology
Male
Medical research
Medicine
Medicine & Public Health
Medicine, Experimental
Middle Aged
Original Article
Palliative Care
Prevalence
Renal Insufficiency, Chronic - diagnosis
Renal Insufficiency, Chronic - physiopathology
Retrospective Studies
Risk Assessment
Risk Factors
Tetralogy of Fallot
Tetralogy of Fallot - surgery
Type 2 diabetes
Vascular Surgery
Young Adult
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Summary:Long-term survival after tetralogy of Fallot (TOF) repair is excellent. However, little is published regarding late noncardiac complications. This study aimed to determine the prevalence and risk factors for renal dysfunction among adults after TOF repair. For this study, 56 adult patients with complete repair of TOF were identified, and their charts were retrospectively reviewed. An estimated glomerular filtration rate (eGFR) for each patient was calculated using the Modification of Diet in Renal Disease formula (MDRD). Using each patient’s eGFR, he or she was classified into stages based on the National Kidney Foundation chronic kidney disease (CKD) staging. Clinical parameters were compared among patients with and those without renal dysfunction to identify risk factors for renal impairment. The median estimated eGFR rate for the cohort was 78 ml/min/1.73 m 2 . Based on the National Kidney Foundation CKD staging system, 54 % of the patients had at least stage 2 chronic renal disease. The risk factors identified were hypertension ( p  
ISSN:0172-0643
1432-1971
DOI:10.1007/s00246-012-0408-3