Estrous cycle variation in anxiolytic-like effects of topiramate in Wistar rats in two animal models of anxiety-like behavior

The anxiolytic-like effects of topiramate were assessed during several estrous cycle phases in Wistar rats tested in two animal models of anxiety-like behavior. In a conflict operant test, during proestrus, diazepam (1.3, 2.0mg/kg; P

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Bibliographic Details
Published in:Pharmacology, biochemistry and behavior biochemistry and behavior, 2013-01, Vol.103 (3), p.631-636
Main Authors: Molina-Hernández, Miguel, Téllez-Alcántara, N. Patricia, Olivera-López, Jorge I., Jaramillo, M. Teresa
Format: Article
Language:English
Subjects:
Animals
Anti-Anxiety Agents - pharmacology
Anti-Anxiety Agents - therapeutic use
Anxiety - drug therapy
Anxiety - physiopathology
Conditioning, Operant - drug effects
Conflict behavior
Diazepam
Diazepam - pharmacology
Disease Models, Animal
Dose-Response Relationship, Drug
Elevated plus-maze
Estrous cycle
Estrous Cycle - drug effects
Female
Fructose - analogs & derivatives
Fructose - pharmacology
Fructose - therapeutic use
Maze Learning - drug effects
Rats
Rats, Wistar
Topiramate
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Summary:The anxiolytic-like effects of topiramate were assessed during several estrous cycle phases in Wistar rats tested in two animal models of anxiety-like behavior. In a conflict operant test, during proestrus, diazepam (1.3, 2.0mg/kg; P
ISSN:0091-3057
1873-5177
DOI:10.1016/j.pbb.2012.11.002