Reduction- and thermo-sensitive star polypeptide micelles and hydrogels for on-demand drug delivery

Dual stimuli-sensitive star polypeptide was for the first time synthesized and self-assembled into reduction- and thermo-sensitive micelles and hydrogels, demonstrating tunable size, mechanical and triggered drug-release properties useful for on-demand drug delivery.

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2013-02, Vol.49 (12), p.1229-1231
Main Authors: Liu, Dong-Lin, Chang, Xiao, Dong, Chang-Ming
Format: Article
Language:English
Subjects:
Doxorubicin - chemistry
Drug Carriers - chemistry
Hydrogels - chemistry
Lactic Acid - chemistry
Micelles
Oxidation-Reduction
Peptides - chemistry
Polyglycolic Acid - chemistry
Temperature
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Description
Summary:Dual stimuli-sensitive star polypeptide was for the first time synthesized and self-assembled into reduction- and thermo-sensitive micelles and hydrogels, demonstrating tunable size, mechanical and triggered drug-release properties useful for on-demand drug delivery.
ISSN:1359-7345
1364-548X
DOI:10.1039/c2cc38343h